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Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions: A case report.
World J Clin Cases
January 2025
Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu 42601, South Korea.
Background: The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics, increasingly supported by molecular genetic diagnostics. Data on neurotrophic tyrosine receptor kinase () gene fusion-positive uterine sarcoma, potentially aggressive and morphologically similar to fibrosarcoma, are limited due to its recent recognition. Pan-TRK immunohistochemistry (IHC) analysis serves as an effective screening tool with high sensitivity and specificity for -fusion malignancies.
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Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
A 5-year-old male with xeroderma pigmentosum from Honduras presented with a rapidly growing mass on the left post-auricular neck, associated with left-sided hearing loss. MRI revealed a large mass with invasion of the external auditory canal, temporal bone, and metastasis to lymph nodes. Biopsy confirmed moderately differentiated squamous cell carcinoma (SCC).
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Vascular malformations (VMs) are dysplastic abnormalities of vascular channels, differing from vascular tumors by their slow growth. Arteriovenous malformations (AVMs) arise between weeks 4-10 of intrauterine life, with a prevalence of 1 in 100,000 among Caucasians. Common in the head, neck, and hands, AVMs may be asymptomatic or cause symptoms like pain, deformity, and disability.
View Article and Find Full Text PDFRare Case of Immediate Postoperative Acute Gout Flare Associated With Surgical Management of Facial Abscess of Odontogenic Origin-Case Report.
Mil Med
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Gout is caused by monosodium urate crystal deposition within joints and periarticular structures. It is characterized by the typical arthritis symptoms such as pain, swelling, and redness usually involving the first metatarsophalangeal joint. Recurrent attacks of gout are common, especially after major surgical procedures during which intense cell turnover takes place and can lead to hyperuricemia and accumulation of monosodium urate crystals.
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