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Blastomycosis of the scrotum: Not a fun guy.
Urol Case Rep
January 2025
Lakeridge Health Oshawa, Hospital Ct, Oshawa, ON, L1G 8A2, Canada.
is a fungal pathogen endemic to North America. Infection from inhalation of its conidia has diffuse clinical manifestations. These can include genitourinary system infections which may manifest as ulcerative, draining skin lesions.
View Article and Find Full Text PDFA Small-Molecule Drug for the Self-Checking of Mitophagy.
Angew Chem Int Ed Engl
January 2025
National University of Singapore, Dept of Diagnostic Radiology, SINGAPORE.
Mitophagy that disrupt mitochondrial membrane potential (MMP), represents a critical focus in pharmacology. However, the discovery and evaluation of MMP-disrupting drugs are often hampered using commercially available marker molecules that target similar or identical zones. These markers can significantly interfere with, obscure, or amplify the functional effects of MMP-targeting drugs, frequently leading to clinical failures.
View Article and Find Full Text PDFProfiling Genome-Wide Methylation Patterns in Cattle Infected with .
Int J Mol Sci
December 2024
Animal Genomics and Improvement Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA.
DNA methylation (DNAm) regulates gene expression and genomic imprinting. This study aimed to investigate the effect of gastrointestinal (GI) nematode infection on host DNAm. Helminth-free Holstein steers were either infected with (the brown stomach worm) or given tap water only as a control.
View Article and Find Full Text PDFInosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages.
Molecules
December 2024
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, National-Local Joint Engineering Research Center of Entomoceutics, College of Pharmacy, Dali University, Dali 671000, China.
Inosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26 through modulation of macrophage phenotypes. Aside from the already reported effects of inosine on T cells, in this study, in vitro experiments revealed that inosine could modulate macrophage phenotype.
View Article and Find Full Text PDFMaking Deception Fun: Teaching Autistic Individuals How to Play Friendly Tricks.
Behav Anal Pract
December 2024
Center for Autism and Related Disorders, Inc, Woodland Hills, Los Angeles, CA USA.
Perspective taking is a critical repertoire for navigating social relationships and consists of a variety of complex verbal skills, including socially adaptive forms of deception. Detecting and being able to use socially adaptive deception likely has many practical uses, including defending oneself against bullying, telling white lies to avoid hurting others' feelings, keeping secrets and bluffing during games, and playing friendly tricks on others. Previous research has documented that some Autistic children have challenges identifying deception and playfully deceiving others (Reinecke et al.
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