For the first half of this century there was no major dispute over the criteria for death. This was to change dramatically with major technological breakthroughs in modern medicine starting with the advent of the respirators. The consequences of their use raised serious questions about the traditional ways of diagnosing death. Today there are two different philosophical positions about what it means to be dead in terms of brain functions: One, which is not currently law in any jurisdiction, would pronounce a person dead when there is an irreversible loss of higher brain functions. This has been called cognitive death. The patient is not in a coma, because arousal mechanisms are present, the brain stem functions being relatively intact. The other philosophical position considers a person dead if there is an irreversible loss of the functions of the brain stem or the entire brain. The neurologic syndrome of brain death has been accepted by the medical profession as a distinct clinical entity that experienced physicians can diagnose with an extremely high degree of certainty, and can usually easily be distinguished from other neurologic syndromes. However, we must not lose sight of the fact that this is less a conclusion than a beginning. It is the task of philosophy to offer analyses of personhood and of personal identity that might support practical formulations for the determination of death and theology has reflected upon the meaning of death, if not its definition, from time immemorial. To define the death of a human being we must recognize the characteristics that are essential to humaneness. It is quite inadequate to limit the discussion to the death of the heart or the brain.
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Int J Drug Policy
January 2025
MGH Institute for Technology Assessment, Harvard Medical School, Boston, MA, 02144, USA. Electronic address:
The overdose epidemic in the United States is evolving, with a rise in stimulant (cocaine and/or methamphetamine)-only and opioid and stimulant-involved overdose deaths for reasons that remain unclear. We conducted interviews and group model building workshops in Massachusetts and South Dakota. Building on these data and extant research, we identified six dynamic hypotheses, explaining changes in stimulant-involved overdose trends, visualized using causal loop diagrams.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2025
Department of Ultrasonography, Fuwai Yunnan Hospital, Chinese Academy of Medical, Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming, 650102, China. Electronic address:
Pulmonary arterial hypertension (PAH) is a syndrome characterized by increased pulmonary vascular resistance and elevated pulmonary artery pressure, ultimately leading to right heart failure and even death. Increasing evidence implicates the fat mass and obesity-associated protein (FTO) in various metabolic and inflammatory pathways; however, its role in pulmonary endothelial function and PAH remains largely unexplored. In this study, we examined the effects of endothelial cell-specific FTO knockout on PAH development.
View Article and Find Full Text PDFPlant Dis
January 2025
50 Yonsei-ro, Seodaemun-guSeoul, Korea (the Republic of), 03722;
Fire blight, a devastating bacterial disease affecting rosaceous plants such as apples and pears, is caused by . The disease, known for its rapid spread and destructive potential, can lead to severe symptoms and often result in the death of infected plants. In Korea, the observation of was first recorded in 2015, and subsequent dissemination has been noted across the peninsula.
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December 2025
National Influenza Centre, Edificio Rondilla, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Influenza accounts for 30% of the total morbidity and mortality in the European Union. However, the specific burden in different European countries is largely unknown, and more research is needed to ascertain the reality of this disease. In this retrospective study, we analyzed the burdens of hospitalization, intensive care unit (ICU) admission and in-hospital mortality in Spain over five seasons (2015-2020) via publicly available Minimum Basic Datasets (MDBS).
View Article and Find Full Text PDFChaos
January 2025
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Spirals are a special class of excitable waves that have its significance in the understanding of cardiac arrests and neuronal transduction. In a theoretical model of the chemical Belousov-Zhabotinsky reaction system, we explore the dynamics of the spatiotemporal patterns that emerge out of competing reaction and diffusion phenomena. By modifying the existing mathematical models of the reaction kinetics, we have been able to explore the explicit effect of hydrogen ion concentration in the system, so as to achieve various regimes of wave activity, from stable spirals to oscillation death.
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