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Microfluidic platforms for monitoring cardiomyocyte electromechanical activity.
Microsyst Nanoeng
January 2025
School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), 250353, Jinan, China.
Cardiovascular diseases account for ~40% of global deaths annually. This situation has revealed the urgent need for the investigation and development of corresponding drugs for pathogenesis due to the complexity of research methods and detection techniques. An in vitro cardiomyocyte model is commonly used for cardiac drug screening and disease modeling since it can respond to microphysiological environmental variations through mechanoelectric feedback.
View Article and Find Full Text PDFUpper Leg Muscular Co-Contraction During Maximal-Speed Sprinting in Male Club Ice Hockey Athletes.
Sports Med Open
January 2025
Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
Background: Little is known about the lower extremity muscle co-contraction patterns during sprinting and its relation to running velocity (i.e., performance).
View Article and Find Full Text PDFRiluzole is associated with reduced risk of heart failure.
Eur J Neurol
January 2025
Department of Pharmacotherapy, University of Utah Health, Salt Lake City, Utah, USA.
Background: Reduction of intracellular Na accumulation through late Na current inhibition has been recognized as a target for cardiac Ca handling which underlies myocardial contractility and relaxation in heart failure (HF). Riluzole, an Na channel blocker with enhancement of Ca-activated K channel function, used for management of amyotrophic lateral sclerosis (ALS), is effective in suppressing Ca leak and therefore may improve cardiac function.
Objectives: The study aim was to investigate whether riluzole lowers HF incidence.
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Alzheimers Dement
December 2024
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Background: The relationships of left atrial (LA) dysfunction with cognition are poorly understood. We investigated the associations of LA function with cognitive impairment, etiologic-subtype (neurodegenerative vs. vascular[VCI]), neuroimaging markers of cerebrovascular disease (CeVD) and circulating biomarkers, in subjects without AF.
View Article and Find Full Text PDFClinical and Diagnostic Value of ABCDE Stress Echocardiography With Exercise in Patients With Myocardial Infarction.
Kardiologiia
December 2024
Moiseev Department of Internal Diseases with a Course of Cardiology and Functional Diagnostics, Medical Institute, Patrice Lumumba Peoples' Friendship University of Russia, Moscow.
Aim: Evaluation of the clinical and diagnostic role of stepwise stress echocardiography (Stress Echo) with exercise using the ABCDE protocol in patients with myocardial infarction (MI).
Material And Methods: This single-site study included 75 patients (mean age 61.6±9.
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