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Identification of anti-SARS-CoV-2 compounds from Qingwen Zhike prescription and exploration of their underlying mechanism by UPLC-Q-Exactive Orbitrap MS, high-throughput screening assays and transmission electron microscopy.
J Pharm Biomed Anal
December 2024
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address:
Qingwen Zhike prescription (QWZK), a traditional Chinese medicine (TCM) hospital prescription developed in response to the corona virus disease 2019 (COVID-19) pandemic, has demonstrated efficacy in clinical practice. Nevertheless, its specific antiviral components and mechanisms of action remain unclear. This study screened the antiviral compounds against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from Qingwen Zhike prescription and explored the underlying mechanism through chemical composition analysis, serum and lung exposure profiles analysis, high-throughput screening, and transmission electron microscopy (TEM) observation.
View Article and Find Full Text PDFLongitudinal analysis of serum intestinal fatty acid-binding protein in a patient with non-occlusive mesenteric ischemia following brachial plexus block-induced hypotension: a case study.
Clin J Gastroenterol
December 2024
Department of Nephrology, Saiseikai Niigata Kenoh Kikan Hospital, Sanjo, Niigata, 955-0091, Japan.
Intestinal fatty acid-binding protein (I-FABP) is a promising biomarker for small-bowel ischemia including non-occlusive mesenteric ischemia (NOMI). A 75-year-old woman with diabetic nephropathy sustained a distal radius fracture. Two days later, she underwent a brachial plexus block to facilitate orthopedic surgery, which resulted in hypotension.
View Article and Find Full Text PDFComparison of vasopressors for management of hypotension in high-risk caesarean section under neuraxial anesthesia: a systematic review and network meta-analysis.
BMC Anesthesiol
December 2024
Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- Vasopressors like ephedrine, noradrenaline, and phenylephrine are used to manage hypotension during Caesarean sections in high-risk pregnant women receiving neuraxial anesthesia, but the best option is still being researched.
- In a study analyzing 13 trials with 1,262 patients, it was found that while no significant differences were noted in hypotension episodes among the vasopressors, phenylephrine was ranked as the most effective in preventing hypotension.
- Additionally, those on phenylephrine experienced higher rates of bradycardia, but lower instances of nausea and vomiting compared to those on ephedrine, with no major differences in fetal outcomes between noradrenaline and phenylephrine.
[Analysis of Overdose-related Posts on Social Media].
Yakugaku Zasshi
December 2024
Division of Drug Informatics, Keio University Faculty of Pharmacy.
Article Synopsis
- Intentional overdoses (OD) of OTC and prescription drugs are increasingly becoming a global issue, and there’s a lack of social media-focused research on this topic.* -
- This study analyzed over 30,000 Japanese Twitter posts related to "OD" using advanced language processing techniques, identifying specific drug mentions and emotional tones.* -
- Findings indicated a significant correlation between negative emotions and OD incidents, highlighting the potential of social media surveillance in identifying high-risk individuals and shaping prevention efforts.*
Efficacy and safety of ephedra-containing oral medications: a systematic review, meta-analysis, and exploratory dose-response analysis for weight reduction.
Front Pharmacol
October 2024
College of Korean Medicine, Wonkwang University, Iksan, Republic of Korea.
Introduction: Despite the widespread use of ephedra in various forms, including food supplements and herbal prescriptions, comprehensive studies reviewing its efficacy and safety across different countries are lacking.
Methods: We systematically searched 5 electronic databases and conducted a meta-analysis of 16 randomized controlled trials (RCTs) on ephedra-containing oral medications (EOMs), performing a dose-response analysis for weight loss.
Results: The meta-analysis results revealed a statistically significant reduction in the body mass index (BMI) (MD: 1.
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