AI Article Synopsis
- The study investigated how astaxanthin affects endurance capacity in young male mice over a 5-week period.
- Mice treated with astaxanthin demonstrated longer swimming times and lower blood lactate levels compared to the control group.
- Astaxanthin also helped maintain higher levels of plasma non-esterfied fatty acids and glucose during exercise, while reducing fat accumulation, indicating improved fatty acid utilization for energy.
Article Abstract
The present study was designed to determine the effect of astaxanthin on endurance capacity in male mice aged 4 weeks. Mice were given orally either vehicle or astaxanthin (1.2, 6, or 30 mg/kg body weight) by stomach intubation for 5 weeks. The astaxanthin group showed a significant increase in swimming time to exhaustion as compared to the control group. Blood lactate concentration in the astaxanthin groups was significantly lower than in the control group. In the control group, plasma non-esterfied fatty acid (NEFA) and plasma glucose were decreased by swimming exercise, but in the astaxanthin group, NEFA and plasma glucose were significantly higher than in the control group. Astaxanthin treatment also significantly decreased fat accumulation. These results suggest that improvement in swimming endurance by the administration of astaxanthin is caused by an increase in utilization of fatty acids as an energy source.
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| http://dx.doi.org/10.1248/bpb.29.2106 | DOI Listing |
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