A model for an isothermal gel-liquid crystalline transition induced by ionic binding is proposed. A Ginsburg-Landau functional was used to describe the long-range order that spontaneously arises during the transition. By calculation of the corresponding chemical potential we obtain the mass current of phospholipids in gel-phase described by an order parameter. In the conservation of mass equation the kinetics of the phospholipids-calcium interaction is introduced, together with the flux divergency. A circular membrane is considered for the analysis, so that the model can be studied in polar coordinates. A solution approximated to first order shows an heterogeneous distribution of domains of phospholipids in gel and liquid crystalline phases. These spatial domains have been detected experimentally by diverse methods in vesicles and cellular membranes. Spatial heterogeneities may cause destabilization of the membrane in the boundaries between domains. This may explain the enhanced vesicle fusion observed in the presence of Ca2+.
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