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A generative framework for enhanced cell-type specificity in rationally designed mRNAs.
bioRxiv
December 2024
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
mRNA delivery offers new opportunities for disease treatment by directing cells to produce therapeutic proteins. However, designing highly stable mRNAs with programmable cell type-specificity remains a challenge. To address this, we measured the regulatory activity of 60,000 5' and 3' untranslated regions (UTRs) across six cell types and developed PARADE (Prediction And RAtional DEsign of mRNA UTRs), a generative AI framework to engineer untranslated RNA regions with tailored cell type-specific activity.
View Article and Find Full Text PDFEffect of Food Deprivation on Plasma Cortisol, Carbohydrate Metabolism, and Histomorphology in Clarias batrachus.
Cell Biochem Biophys
January 2025
Department of Zoology, Aligarh Muslim University, Aligarh, UP, India.
The nutritional status of fish is essential for its health, experimental studies, and aquaculture practices. The current study investigated the impact of food deprivation on biochemical parameters, histology of skin, gill, and kidney tissues, and ultrastructure of gills in Clarias batrachus. Fish were subjected to food deprivation for 2, 7, and 15 days resulting in (a) significant increase in plasma cortisol levels, (b) no significant changes in plasma osmolality and plasma glucose content, and (c) significant decrease in liver and muscle glycogen contents.
View Article and Find Full Text PDFBioaccumulation of lead, arsenic, and mercury in vital organs of common carp ( L.): Assessment of pathological effects and possible hazards associated with human consumption.
Open Vet J
November 2024
Department of Pathology and Poultry Disease, College of Veterinary Medicine, University of Diyala, Baqubah, Iraq.
Article Synopsis
- Pollution from heavy metals like arsenic, lead, and mercury poses significant risks to aquatic life, humans, and the ecosystem, leading to health concerns after consuming contaminated fish.
- The study focused on assessing the levels of these metals in common carp from Baqubah, Iraq, to understand their impact on human health and aquaculture practices.
- Results indicated that while arsenic and lead levels were within safe limits set by WHO, mercury levels exceeded those limits, and histopathological damage in fish organs highlighted the adverse effects of metal exposure.
Longitudinal Body Composition Identifies Hepatocellular Carcinoma With Cachexia Following Combined Immunotherapy and Target Therapy (CHANCE2213).
J Cachexia Sarcopenia Muscle
December 2024
Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Article Synopsis
- The study investigates the impact of cancer cachexia in patients with hepatocellular carcinoma (HCC), focusing on how body composition changes over time can help identify cachexia.
- It utilizes a cohort of unresectable HCC patients treated with specific therapies, analyzing body composition through CT scans to categorize patients into different cachexia phases based on their skeletal muscle mass and total adipose tissue.
- Findings reveal that patients experiencing significant declines in muscle and tissue mass have worse overall survival outcomes, highlighting the importance of monitoring body composition in HCC treatment plans.
The Effects of Testosterone Replacement Therapy in Adult Men With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-analysis.
Clin Transl Gastroenterol
November 2024
Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University, St Louis, Missouri, USA.
Article Synopsis
- The study investigates the effects of testosterone therapy (TT) on men with metabolic dysfunction-associated steatotic liver disease (MASLD), aiming to see if it can slow down disease progression.
- A systematic review analyzed 9 studies, including randomized and non-randomized trials, which showed that TT consistently reduced liver steatosis and fibrosis compared to no treatment.
- The findings suggest TT could be an effective treatment for men with MASLD and low testosterone, but more rigorous, large-scale trials are necessary for conclusive results.
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