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Purpose: To examine associations between lumbar intervertebral disc degeneration (LDD) and type II Modic changes (MC) when retaining information at each interspace ("interspace-level analysis"), as compared to aggregating information across interspaces as is typically done in spine research ("person-level analysis"). The study compared results from (1) interspace-level analyses assuming a common relationship across interspaces (the "interspace-level, common-relationship" approach), (2) interspace-level analyses allowing for interspace-specific associations (an "interspace-level, interspace-specific" approach), and (3) a conventional person-level analytic approach.
Methods: Adults in primary care (n=147) received lumbar spine magnetic resonance imaging (MRI) and neuroradiologist-evaluated assessments of prevalent disc height narrowing (DHN), type II MC, and other LDD parameters.
This study aimed to delineate trends in intervertebral disc degeneration among Mexican patients, specifically focusing on the distribution and correlation between BMI and Pfirrmann classification results within the Mexican population. Conducted using the public health database of Mexico City. The study involved 51 patients sampled via convenience sampling, with exclusive utilization of internal MRI data from L4-L5 and L5-S1 discs.
View Article and Find Full Text PDFKlotho mutation does not accelerate intervertebral disc aging in mice.
FASEB J
January 2025
HSS Research Institute, Hospital for Special Surgery, New York, New York, USA.
Aging is a risk factor for several chronic conditions, including intervertebral disc degeneration and associated back pain. Disc pathologies include loss of reticular-shaped nucleus pulposus cells, disorganization of annulus fibrosus lamellae, reduced disc height, and increased disc bulging. Sonic hedgehog, cytokeratin 19, and extracellular matrix proteins are markers of healthy disc.
View Article and Find Full Text PDFLumbar disc space height in relation to neural foraminal dimensions and patient characteristics: A morphometric analysis from L1-S1 using computed tomography.
Brain Spine
December 2024
Departments of Orthopaedic Surgery and Neurological Surgery, Duke University Health System, Durham, NC, USA.
Introduction: The normative relationship between lumbar intervertebral disc space height (DSH) and neuroforaminal dimensions (NFD) has yet to be defined.
Research Question: The purpose of this study was to investigate the relationship between lumbar DSH and NFD using computed tomography (CT), accounting for influences of patient demographic and anthropometric characteristics.
Materials And Methods: We analyzed CT imaging of 350 female and 350 male patients.
Polysaccharide-based biomaterials for regenerative therapy in intervertebral disc degeneration.
Mater Today Bio
February 2025
Department of Orthopaedic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou Medical College, Soochow University, Suzhou, 215000, China.
Intervertebral disc (IVD) degeneration represents a significant cause of chronic back pain and disability, with a substantial impact on the quality of life. Conventional therapeutic modalities frequently address the symptoms rather than the underlying etiology, underscoring the necessity for regenerative therapies that restore disc function. Polysaccharide-based materials, such as hyaluronic acid, alginate, chitosan, and chondroitin sulfate, have emerged as promising candidates for intervertebral disc degeneration (IVDD) therapy due to their biocompatibility, biodegradability, and ability to mimic the native extracellular matrix (ECM) of the nucleus pulposus (NP).
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