AI Article Synopsis
- The study aimed to assess how well contrast-enhanced color duplex sonography (CDS) can predict tumor hypoxia in patients with metastatic neck lymph nodes from head and neck cancers.
- In the study, 25 patients underwent imaging with a contrast agent to visualize blood vessels, and the extent of vascularization was measured using a metric called color pixel density (CPD) against various levels of oxygenation (pO2).
- Results showed a moderate to high correlation between CPD and low oxygen readings (pO2 ≤ 5.0 and 10.0 mmHg), indicating that CPD can effectively represent global tumor oxygenation, although it struggles to capture the complexity of vascular variations within tumors.
Article Abstract
Purpose: To evaluate the predictive value of radiotherapeutically relevant tumor hypoxia by contrast-enhanced color duplex sonography (CDS). The objectification was based on pO(2) histography.
Material And Methods: 25 patients with metastatic neck lymph node from a primary squamous carcinoma of the head and neck were examined. To visualize as many vessels as possible, a contrast enhancer (Levovist), Schering Corp., Germany) was administered. Horizontal and longitudinal sonographic scans with a thickness of 5 mm were performed on the metastatic neck lymph node. Color pixel density (CPD) was defined as the ratio of colored to gray pixels in a region of interest. It represents the extent of vascularization in the investigated slice. To assess the biological and clinical relevance of oxygenation measurement, the relative frequency of pO(2) readings < or = 2.5, 5.0, and 10.0 mmHg, as well as mean and median pO(2), were documented.
Results: In order to investigate the degree of linear association, the Pearson correlation coefficient was calculated. Moderate (/r/ > 0.5) to high (/r/ > 0.7) correlation was found between the CPD and the parameters of hypoxic fraction (pO(2) readings with values < or = 5.0 and 10.0 mmHg, as well as mean and median). There was only a slight correlation between CPD and the fraction of pO(2) values < or = 2.5 mmHg (r = -0.479).
Conclusion: CPD represents the mean degree of vascularization. As a noninvasive measurement, this method seems feasible for evaluating the state of global oxygenation in superficial tumors. Nevertheless, this method is limited through its deficiency in describing the vascular heterogeneity of tumors.
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| http://dx.doi.org/10.1007/s00066-006-1520-1 | DOI Listing |
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