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Langerhans cells (LCs) are distinct among phagocytes, functioning both as embryo-derived, tissue-resident macrophages in skin innervation and repair and as migrating professional antigen-presenting cells, a function classically assigned to dendritic cells (DCs). Here, we demonstrate that both intrinsic and extrinsic factors imprint this dual identity. Using ablation of embryo-derived LCs in the murine adult skin and tracking differentiation of incoming monocyte-derived replacements, we found intrinsic intraepidermal heterogeneity.

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Article Synopsis
  • - The study investigates the presence of axonal spheroids in motor axons and C-fibers of patients with amyotrophic lateral sclerosis (ALS) using corneal confocal microscopy and skin biopsies.
  • - It involved 31 ALS patients and 20 healthy subjects, measuring various nerve fiber metrics and dendritic cell density, revealing that ALS patients had more axonal spheroids and higher dendritic cell density compared to controls.
  • - The findings suggest that analyzing dendritic cells and axonal structures in ALS patients may help understand the disease's mechanisms and identify potential biomarkers for diagnosis or monitoring.
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IFN-γ-dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis.

J Allergy Clin Immunol

December 2023

Immunosurveillance Laboratory, The Francis Crick Institute, London, United Kingdom; Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom; Centre for Inflammation Biology and Cancer Immunology, King's College London, London, United Kingdom. Electronic address:

Background: Elicitation of allergic contact dermatitis (ACD), an inflammatory type 4 hypersensitivity disease, induces skin infiltration by polyclonal effector CD8 αβ T cells and precursors of tissue-resident memory T (T) cells. Because T have long-term potential to contribute to body-surface immunoprotection and immunopathology, their local regulation needs a fuller understanding.

Objective: We sought to investigate how T-cell maturation might be influenced by innate-like T cells pre-existing within many epithelia.

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The detectability of intraepidermal melanocytes-A narrative review of immunohistochemical studies.

J Cutan Pathol

December 2022

Department of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, Toruń, Poland.

Some intraepidermal lesions, even the nonmelanocytic ones, may mimic melanoma in situ. The cytoplasmic clarity in atypical basal cells, architectural disorder with cell aggregates or nest-like structures within the epidermis often cause challenge particularly in sun-damaged skin. The aim of this review is to evaluate the effectiveness of the most often used immunohistochemical melanocyte markers in the diagnosis of intraepidermal lesions.

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Background: Atypical intraepidermal melanocytic proliferations (AIMP) is a descriptive term sometimes applied to biopsies that do not fulfill diagnostic criteria of melanoma. They are common on sun-damaged skin, but their definition and management are controversial.

Objective: To describe dermoscopic (DS), reflectance confocal microscopic (RCM) and histopathological features of AIMP and identify features associated with subsequent melanoma in situ (MIS).

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