Comparisons of the 1.84-Mb genome of serotype M5 Streptococcus pyogenes strain Manfredo with previously sequenced genomes emphasized the role of prophages in diversification of S. pyogenes and the close relationship between strain Manfredo and MGAS8232, another acute rheumatic fever-associated strain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797351PMC
http://dx.doi.org/10.1128/JB.01227-06DOI Listing

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