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The nuclear lamin network passively responds to both active or passive cell movement through confinements.
Soft Matter
January 2025
Laboratoire de Physique de l'École normale supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, F-75005 Paris, France.
Physical models of cell motility rely mostly on cytoskeletal dynamical assembly. However, when cells move through the complex 3D environment of living tissues, they have to squeeze their nucleus that is stiffer than the rest of the cell. The lamin network, organised as a shell right underneath the nuclear membrane, contributes to the nuclear integrity and stiffness.
View Article and Find Full Text PDFAn In-Vitro Study of the Root Canal Configuration of Mandibular First Premolars in a Bengali Subpopulation Using Cone-Beam Computed Tomography.
Cureus
December 2024
Oral and Maxillofacial Radiology, Oromax Imaging, Kolkata, IND.
Aim: This study aims to analyze the root canal configuration system of mandibular first premolars in the Bengali subpopulation using cone-beam computed tomography (CBCT).
Materials And Methods: Based on Vertucci's classification, the root canal morphology of 100 randomly selected mandibular first premolars in 56 males and 44 females from the Bengali subpopulation of West Bengal was assessed in vitro. The location of the apical foramen, lateral canal, C-shaped canal, types of canal orifice cross-sections, minor constriction diameter, tooth length, and root length were noted.
Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction.
Nat Commun
January 2025
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.
Chronic allodynia stemming from peripheral stump neuromas can persist for extended periods, significantly compromising patients' quality of life. Conventional managements for nerve stumps have demonstrated limited effectiveness in ensuring their orderly termination. In this study, we present a spatially confined conduit strategy, designed to enhance the self-organization of regenerating nerves after truncation.
View Article and Find Full Text PDFTeratological abnormalities in hard ticks (Acari: Ixodidae) from Pakistan.
Exp Appl Acarol
December 2024
Department of Zoology, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan.
Studying teratological abnormalities in ticks are taxonomically important because this poorly understood biological phenomenon causes difficulties in tick's identification. Globally, reports regarding these abnormalities in ticks, reasons of their causes and their impacts are scarce. According to the available published data, there are no studies regarding teratological abnormalities in ticks from Pakistan.
View Article and Find Full Text PDFPosterior Reversible Encephalopathy Syndrome Associated With a Pontine Lacunar Infarct in a Severely Hypertensive Patient: A Case Report.
Cureus
November 2024
Internal Medicine, Wellington Regional Medical Center, Wellington, USA.
Posterior reversible encephalopathy syndrome (PRES) is a neurologic condition defined by symptoms and imaging findings secondary to vasogenic edema in the brain. Even though not all hypertensive individuals will progress to PRES, high blood pressure is the most frequent risk factor associated with the condition. The pathophysiology of PRES is not clearly understood, but the most accepted proposed mechanism focuses on the brain's inability to regulate cerebral blood flow through constriction or dilation of vessels during extreme blood pressure.
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