AI Article Synopsis
- The study aimed to explore how the length of mucin 6 (MUC6) VNTR segments relates to H pylori infections in patients undergoing endoscopy.
- Blood samples were taken from 160 patients, and their MUC6 genotypes were categorized as long or short, with H pylori diagnosed through a breath test.
- Results showed that shorter MUC6 alleles were linked to a higher prevalence of H pylori infection among patients, indicating a significant relationship.
Article Abstract
Aim: To investigate the relationship between mucin 6 (MUC6) VNTR length and H pylori infection.
Methods: Blood samples were collected from patients visiting the Can Tho General Hospital for upper gastrointestinal endoscopy. DNA was isolated from whole blood, the repeated section was cut out using a restriction enzyme (Pvu II) and the length of the allele fragments was determined by Southern blotting. H pylori infection was diagnosed by (14)C urea breath test. For analysis, MUC6 allele fragment length was dichotomized as being either long (> 13.5 kbp) or short (< or = 13.5 kbp) and patients were classified according to genotype [long-long (LL), long-short (LS), short-short (SS)].
Results: 160 patients were studied (mean age 43 years, 36% were males, 58% H pylori positive). MUC6 Pvu II-restricted allele fragment lengths ranged from 7 to 19 kbp. Of the patients with the LL, LS, SS MUC6 genotype, 43% (24/56), 57% (25/58) and 76% (11/46) were infected with H pylori, respectively (P = 0.003).
Conclusion: Short MUC6 alleles are associated with H pylori infection.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124411 | PMC |
| http://dx.doi.org/10.3748/wjg.v12.i37.6021 | DOI Listing |
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