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Successful Management of Severe Dengue With Gastrointestinal Bleeding: A Case Report Highlighting Endoscopic Hemostasis.
Cureus
November 2024
Internal Medicine, Al Qassimi Hospital, Sharjah, ARE.
Dengue fever, caused by the dengue virus and transmitted by mosquitoes, poses a significant global health threat, particularly in tropical and subtropical regions. Severe cases can manifest as dengue hemorrhagic fever (DHF) or dengue shock syndrome, leading to complications such as plasma leakage, fluid accumulation, respiratory distress, severe bleeding, and organ impairment. Among these complications, gastrointestinal (GI) bleeding is particularly concerning due to its potential to rapidly deteriorate the patient's condition.
View Article and Find Full Text PDFNatural Compounds and Their Analogs as Antivirals Against Dengue Virus: A Review.
Phytother Res
December 2024
Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Kabupaten Bogor, Jawa Barat, Indonesia.
Dengue virus (DENV) continues to pose a significant global health challenge, causing diseases such as dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. While efforts in vaccine development and antiviral drug discovery are ongoing, effective therapeutic options remain limited. In this review, we highlight natural compounds and the analogs that demonstrated antiviral activity against DENV in in vitro and in vivo studies.
View Article and Find Full Text PDFThe role of the radiologist in the dengue endemic: a pictorial essay.
Radiol Bras
December 2024
Hospital Universitário de Brasília/Universidade de Brasília (HUB/UnB), Hospital Sírio-Libanês Brasília, Laboratório Exame/DASA, Brasília, DF, Brazil, Hospital Santa Marta (HSM), Taguatinga, DF, Brazil.
The dengue virus, a member of the family Flaviviridae, is transmitted by mosquitoes and causes a viral disease known as dengue fever that is prevalent in tropical and subtropical regions. It is estimated that there are 100-400 million new infections every year, with underreporting due to limited surveillance systems. The presentation ranges from asymptomatic to dengue shock syndrome.
View Article and Find Full Text PDFPredicting the risk of mortality in children with dengue-induced hepatitis admitted to the paediatric intensive care unit.
World J Crit Care Med
December 2024
Department of Infectious Diseases, The Children's Hospital 2, Ho Chi Minh 700000, Viet Nam.
Background: Dengue-associated acute liver failure (PALF) accounts for a high mortality rate in children admitted to the pediatric intensive care unit (PICU). To date, there is a lack of data on clinical algorithms for estimating the risk of mortality in pediatric patients with dengue-induced severe hepatitis (DISH).
Aim: To determine the prevalence of PALF and identify the predictors of mortality among patients with DISH.
A machine learning-based risk score for prediction of mechanical ventilation in children with dengue shock syndrome: A retrospective cohort study.
PLoS One
December 2024
National Institutes of Biomedical Innovation, AI Nutrition Project, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, Japan.
Background: Patients with severe dengue who develop severe respiratory failure requiring mechanical ventilation (MV) support have significantly increased mortality rates. This study aimed to develop a robust machine learning-based risk score to predict the need for MV in children with dengue shock syndrome (DSS) who developed acute respiratory failure.
Methods: This single-institution retrospective study was conducted at a tertiary pediatric hospital in Vietnam between 2013 and 2022.
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