Objective: The P300 event-related brain potential (ERP) was elicited using a visual three-stimulus oddball paradigm (standard 0.70, target 0.15, non-target 0.15) to examine how target/standard stimulus context affects non-target processing.
Methods: Target/standard discrimination difficulty (easy or difficult) and non-target /target similarity (similar or dissimilar) were manipulated orthogonally. Participants (N=13) were instructed to respond to each infrequent target stimulus by pressing a button.
Results: Target stimuli in all task conditions elicited P3b, which was affected only by the difficulty of target/standard discrimination. When target/standard discrimination was easy, the amplitude of non-target P3 was larger for similar than for dissimilar non-target. In contrast, when target/standard discrimination was difficult, non-target stimuli elicited P3a, the amplitude of which was larger for dissimilar than for similar non-target. Thus, the P300 component for non-target stimuli and the pattern of the effect of target similarity on each P300 component varied as a function of the target/standard stimulus context.
Conclusions: The target/standard stimulus context influences the attentional set for stimulus processing such that it determines whether non-target stimuli are processed as task-relevant or distractor information.
Significance: The present results are important for understanding the mechanism of cognitive modification in non-target processing.
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http://dx.doi.org/10.1016/j.clinph.2006.06.755 | DOI Listing |
Front Pharmacol
December 2024
Department of Ophthalmology, Loyola University Chicago, Maywood, IL, United States.
Introduction: This study investigated the efficacy of pooled human immune globulins (Flebogamma DIF) to combat the formation of neutrophil extracellular traps (NETs) and NETosis, along with neutrophil adhesion to corneal epithelial cells in response to dry eye disease relevant stimuli.
Methods: Human neutrophils were isolated by bead-based immunomagnetic depletion of non-target cells from human whole blood. NETosis was induced using phorbol 12-myristate 13-acetate (PMA) or anti-citrullinated histone 4 R3 antibody (H4R3 ACPA).
Biosensors (Basel)
December 2024
Biomedical Science and Engineering Department, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Detecting and tracking the preclinical stages of Alzheimer's disease (AD) is now of particular interest due to the aging of the world's population. AD is the most common cause of dementia, affecting the daily lives of those afflicted. Approaches in development can accelerate the evaluation of the preclinical stages of AD and facilitate early treatment and the prevention of symptom progression.
View Article and Find Full Text PDFJ Adv Res
December 2024
Key Laboratory of Mesoscopic Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, PR China. Electronic address:
Cognition
January 2025
Department of Psychological & Brain Sciences, Washington University in St. Louis, United States of America.
Schizophrenia (Heidelb)
November 2024
Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Freiburg, Germany.
The P3b is a prominent event-related potential (ERP) with maximal amplitude between 250 ms and 500 ms after the onset of a rare target stimulus within a sequence of standard non-target stimuli (oddball paradigm). Several studies found reduced P3b amplitudes in patients with schizophrenia compared to neurotypicals. Our work and the literature suggest that temporal imprecision may play a large pathophysiological role in schizophrenia.
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