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Comparative evaluation of antifungal susceptibility testing methods of invasive Candida species and detection of FKS genes mutations in caspofungin intermediate and resistant isolates.
BMC Infect Dis
January 2025
Department of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Al-Saray Street, Al-Manial, Cairo, 11562, Egypt.
Background: Fungal invasive infections caused by Candida species pose a substantial public health risk with limited therapeutic options. Antifungal susceptibility testing (AFST) is necessary to optimize the therapy. The study aimed to compare different AFST methods of Candida spp.
View Article and Find Full Text PDFBackground: In April 2024, our hospital confirmed a rare case of intra-abdominal infection by Kodamaea ohmeri. The patient sought medical attention at our hospital after taking painkillers orally for one month, experiencing recurrent abdominal pain for 17 days and worsening for 7 days. In March 2024, the patient received symptomatic treatment with oral analgesics (diclofenac sodium) for arthritis.
View Article and Find Full Text PDFDevelopment and application of a LC-HRMS method for simultaneous determination of ten illicit antifungal drugs in herbal bacteriostatic products.
Anal Bioanal Chem
January 2025
Fujian Provincial Center for Disease Control and Prevention (Fujian Academy of Preventive Medicine, Fujian Provincial Key Laboratory of Zoonosis Research), No. 386, Chong'an Road, Jinan District, Fuzhou, 350012, Fujian, China.
The widespread use of sub-therapeutic antibiotics may lead to treatment failures, increased resistance to antibiotics, and even the encouragement of the formation of superbugs. Fraudulent herbal medicines that actually contain unlabeled active ingredients are a global problem. Therefore, streamlined and accurate analytical techniques that can identify and quantify a variety of antimicrobials in suspected illegal products are required.
View Article and Find Full Text PDFAn LCMS/MS method for the simultaneous determination of ten antimicrobials and its application in critically ill patients.
J Pharm Biomed Anal
January 2025
Medical School of Chinese PLA, Beijing 100853, China; Department of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China. Electronic address:
Significant pharmacokinetic variation occurs in critically ill patients, leading to underexposure to antibiotics and poor prognosis. In this study, we developed a simple, sensitive, and fast liquid chromatography tandem mass spectrometry (LCMS/MS) platform for the simultaneous quantification of 8 antibacterial and 2 antifungal drugs, which is optimally suited for clinically efficient, real-time therapeutic drug monitoring (TDM). Multiple reaction monitoring (MRM) mass spectrometry was used in this method, and samples were prepared via protein precipitation with methanol.
View Article and Find Full Text PDFVulvovaginal candidiasis in pregnant women attending a tertiary care centre in North-Eastern India.
Indian J Med Microbiol
December 2024
Department of Obstetrics and Gynaecology, Agartala Government Medical College, Agartala, India. Electronic address:
Article Synopsis
- The study highlights that Candida colonization in the vagina is notably higher during pregnancy, with a prevalence of 35% for Vulvovaginal Candidiasis (VVC) among pregnant women, particularly affecting those with symptoms.
- It compared virulence factors between symptomatic and asymptomatic pregnant women, finding that symptomatic cases had a higher expression of virulence factors, especially with Non-albicans Candida (NAC) strains.
- Antifungal testing revealed that Itraconazole was generally the most effective for treating VVC, but Candida albicans showed the highest sensitivity to fluconazole.
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