AI Article Synopsis
- * Researchers studied HFO patterns in healthy people after stimulating the median nerve in their dominant hand, using advanced brain imaging techniques.
- * In patients with writer's cramp, HFO patterns were found to be weaker and more disorganized, suggesting that these abnormal oscillations could indicate a dysfunction in how the brain processes sensory information related to movement disorders.
Article Abstract
High-frequency oscillations (HFO) have been suggested to reflect the activity of thalamocortical and/or intracortical neurons bursting at high frequencies. These circuits seem to be involved in pathophysiological mechanisms of focal dystonia. In healthy subjects, we characterized the spectrotemporal properties of HFO patterns evoked by dominant-hand median-nerve stimulation, using magnetoencephalography coupled with time-frequency analysis. Then, we investigated HFO in patients with writer's cramp and found that HFO patterns are strongly decreased in power and disorganized in time. This supports the assumption that abnormal HFOs reflect pathophysiological mechanisms occurring in focal dystonia, possibly resulting from a dysfunction of somatosensory processing.
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| http://dx.doi.org/10.1093/brain/awl259 | DOI Listing |
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