The new P.F.C. Sigma RP-F (rotating-platform high-flexion) knee has been designed to permit 155 degrees of flexion after total knee arthroplasty (TKA) without compromising wear, polyethylene contact stresses, patellofemoral tracking, or stability. The purpose of this article is to describe the design features of the P.F.C. Sigma RP-F TKA. It is our belief that future primary posterior-stabilized TKA will incorporate many of the design features of the RP-F knee for improved performance.
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Arthroplast Today
December 2024
Laboratory of Biomechanics, Justus-Liebig-University Gießen, Gießen, Germany.
Background: Application time and viscosity are factors that can significantly affect the properties of bone cement and implant fixation. The aim of this study was to investigate the influence of different application times of 2 different cements on mechanical parameters, cement interdigitation, and cement distribution.
Methods: P.
Sci Rep
October 2024
Department of Biomedical Engineering, Acibadem University, Istanbul, Turkey.
Individuals suffering from obsessive compulsive disorder (OCD) and schizophrenia (SCZ) frequently exhibit symptoms of cognitive disassociations, which are linked to poor functional integration among brain regions. The loss of functional integration can be assessed using graph metrics computed from functional connectivity matrices (FCMs) derived from neuroimaging data. A healthy brain at rest is known to exhibit small-world features with high clustering coefficients and shorter path lengths in contrast to random networks.
View Article and Find Full Text PDFIntroduction: Major depressive disorder (MDD) is a common and disabling mental health condition; the currently available treatments for MDD are insufficient to meet clinical needs due to their limited efficacy and slow onset of action. Hypidone hydrochloride (YL-0919) is a sigma-1 receptor agonist and a novel fast-acting antidepressant that is currently under clinical development.
Methods: To further understand the fast-acting antidepressant activity of YL-0919, this study focused on the role of 5-HTergic neurons in the dorsal raphe nucleus (DRN) in mice.
Arthroplasty
August 2024
Nottingham Elective Orthopaedic Services, Nottingham University Hospitals NHS Trust, Nottingham, NG5 1PB, UK.
Background: The Attune TKR was introduced in 2011 as a successor to its predicate design The PFC Sigma. However, following reports of early failures, there are ongoing concerns related to increased loosening rates. Given the concerns, this study aimed to compare revision rates of the Attune implant to an established predicate, and other implant designs used in a high-volume arthroplasty center.
View Article and Find Full Text PDFBone Jt Open
April 2024
Trauma and Orthopaedics, The Rotherham NHS Foundation Trust Hospital, Rotherham, UK.
Aims: The mean age of patients undergoing total knee arthroplasty (TKA) has reduced with time. Younger patients have increased expectations following TKA. Aseptic loosening of the tibial component is the most common cause of failure of TKA in the UK.
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