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Extraction and characterization of polysaccharide from fermented mycelia of Coriolus versicolor and its efficacy for treating nonalcoholic fatty liver disease.
Int J Biol Macromol
September 2023
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, People's Republic of China. Electronic address:
Coriolus versicolor, a popular traditional Chinese medicinal herb, is widely used in China to treat spleen and liver diseases; however, the beneficial effects of C. versicolor polysaccharides (CVPs) on nonalcoholic fatty liver disease (NAFLD) remain elusive. Herein we isolated and purified a novel CVP (molecular weight, 17,478 Da) from fermented mycelium powder.
View Article and Find Full Text PDFMain-Chain Cationic Bile Acid Polymers Mimicking Facially Amphiphilic Antimicrobial Peptides.
ACS Appl Mater Interfaces
July 2023
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Antibiotic-resistant bacterial infections have led to an increased demand for antibacterial agents that do not contribute to antimicrobial resistance. Antimicrobial peptides (AMPs) with the facially amphiphilic structures have demonstrated remarkable effectiveness, including the ability to suppress antibiotic resistance during bacterial treatment. Herein, inspired by the facially amphiphilic structure of AMPs, the facially amphiphilic skeletons of bile acids (BAs) are utilized as building blocks to create a main-chain cationic bile acid polymer (MCBAP) with macromolecular facial amphiphilicity via polycondensation and a subsequent quaternization.
View Article and Find Full Text PDFα-D-1,3-glucan from Radix Puerariae thomsonii improves NAFLD by regulating the intestinal flora and metabolites.
Carbohydr Polym
January 2023
Jiangxi University of Chinese Medicine, No. 818 Yunwan Road, Nanchang 330002, PR China; Key Laboratory of Modern Preparation of Chinese Medicine of Jiangxi University of Chinese Medicine, No. 818 Yunwan Road, Nanchang 330002, PR China. Electronic address:
Radix Puerariae thomsonii, the root of the botanical family Fabaceae species Pueraria montana var. thomsonii (Benth.) MR Almeida, can be used as food or medicine.
View Article and Find Full Text PDFPreparation, characterization and bioactivities of selenized polysaccharides from Lonicera caerulea L. fruits.
Int J Biol Macromol
January 2023
College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China. Electronic address:
Native polysaccharide was obtained from Lonicera caerulea L. fruits (PLP). Two selenized polysaccharides (PSLP-1 and PSLP-2) were synthesized by the microwave-assisted HNO-NaSeO method, where the selenium (Se) contents were 228 ± 24 and 353 ± 36 μg/g, respectively.
View Article and Find Full Text PDFRecent Progress in Bile Acid-Based Antimicrobials.
Bioconjug Chem
March 2021
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
With the emergence of drug-resistant bacteria and the formation of biofilms by bacteria and fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides (AMPs) have low susceptibility for developing resistance due to the membrane targeted mechanism, but instability and high manufacturing cost limit their applications in clinic. Bile acids, a group of steroids in the human body, with high stability, biocompatibility, and inherent facial amphiphilic structure similar to the characteristics of AMPs, have been applied to the biological field, such as drug delivery systems, self-healing hydrogels, antimicrobials, and so on.
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