AI Article Synopsis
- The study found that 15.9% of diarrhoeic stool samples in Ghana tested positive for noroviruses, highlighting a lack of data on calicivirus incidence in the region.
- Despite differing age groups, noroviruses were only detected during peak diarrhoea times that also aligned with the peak of rotavirus infections.
- The majority of the noroviruses identified were genogroup II (76.9%), with GII-4 being the most prevalent, and some were noted to be recombinants, indicating genetic diversity among the viruses present in Ghanaian children.
Article Abstract
The incidence of calicivirus infection in Ghana and many other African countries is not known. Thirteen (15.9%) of the 82 diarrhoeic stool samples tested for caliciviruses were positive for noroviruses (NoVs). NoVs were present in all age groups and were detected only during the diarrhoea peak that coincided with the peak rotavirus season. Ten (76.9%) of the NoV detected were genogroup II (GII) NoVs and the remaining three (23.1%) genogroup I (GI) NoVs. The predominant GII detected was GII-4 (60%, 6/10). Three of the GII NoVs were determined to be recombinants of GII-8/GII-14 as deduced from the sequencing of the region spanning the Orf1/2 junction. The GII genotypes formed four clusters with published GII sequences. The data shown enhances understanding of NoV diversity in Ghanaian children and demonstrate the global spread of distinct common genotypes to African countries.
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| http://dx.doi.org/10.1002/jmv.20722 | DOI Listing |
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