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Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief.
Nat Commun
December 2024
Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.
The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. Extracellular adenosine alleviates pain by activating the adenosine A1 receptor (A1R).
View Article and Find Full Text PDFAnalysis of oxytocin and oxytocin receptor expressions after hand therapy treatment in a mouse model of chemotherapy-induced peripheral neuropathy .
Neuro Endocrinol Lett
December 2024
Department of Pharmacology, Showa University Graduate School of Medicine, Tokyo, Japan.
Objectives: We aimed to investigate the effect of hand therapy (HT) on oxytocin and oxytocin receptor expression in a chemotherapy-induced peripheral neuropathy (CIPN) model mouse.
Methods: CIPN model mouse was induced by intraperitoneal injection of paclitaxel (PTX; 4 mg/kg) on days 0, 2, 4 and 6 of the study. HT was performed on the CIPN mice once daily for 14 consecutive days, starting on day 8 after the PTX injection.
Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma.
Mol Med
December 2024
Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin er Road, Shanghai, 200025, China.
Background: Glaucoma is a group of heterogeneous neurodegenerative diseases with abnormal energy metabolism and imbalanced neuroinflammation in the retina. Thioredoxin-interacting protein (TXNIP) is involved in glucose and lipid metabolism, and associated with oxidative stress and inflammation, however, not known whether to be involved in glaucoma neuropathy and its underlying mechanisms.
Methods: To establish the chronic ocular hypertension (COH) mice model.
The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.
Netw Neurosci
December 2024
Science for Life Laboratory, Department of Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Striatum, the input stage of the basal ganglia, is important for sensory-motor integration, initiation and selection of behavior, as well as reward learning. Striatum receives glutamatergic inputs from mainly cortex and thalamus. In rodents, the striatal projection neurons (SPNs), giving rise to the direct and the indirect pathway (dSPNs and iSPNs, respectively), account for 95% of the neurons, and the remaining 5% are GABAergic and cholinergic interneurons.
View Article and Find Full Text PDFCT-guided radiofrequency neurotomy (RFN) of bilateral T3-4 sympathetic chain combined with bilateral L3 sympathetic ganglion in patient with palmar hyperhidrosis.
J Surg Case Rep
January 2025
Department of Pain, Meizhou People's Hospital, 514031 Meizhou, Guangdong, China.
Palmoplantar hyperhidrosis is a functional disease with an unknown pathogenesis, making it challenging to find a lasting and effective treatment. This article reports a case of a 43-year-old patient with palmoplantar hyperhidrosis treated with computed tomography (CT)-guided radiofrequency neurotomy (RFN) of bilateral T3-4 sympathetic chain combined with bilateral L3 sympathetic ganglion. The optimal puncture level and skin entry point were selected, and measurements were taken using a CT tool to determine needle depth, angle, and distance from the midline.
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