AI Article Synopsis
- Treatment of facial angiofibromas in tuberous sclerosis is challenging due to the lesions affecting the entire dermis.
- Five patients aged 14 to 33 underwent a surgical procedure that involved excising the lesions and grafting cultured epithelial autografts from their own skin.
- All patients healed well within 10 days post-surgery without significant scarring, although some mild regrowth of lesions was noted five years later, which was considered acceptable.
Article Abstract
Treatment of facial angiofibroma of tuberous sclerosis is problematic, because the skin lesions involve entire dermis. Five patients aged from 14 to 33 (mean: 23.6) years old with angiofibroma of tuberous sclerosis were treated with cultured epithelial autografts between 1995 and 2004. The entire area of the facial lesions was excised using a razor to remove large nodules, and then the remaining lesions were further abraded to a rather deep layer of the dermis to smooth the skin and remove small nodules. Then a cultured autologous epithelium was grafted onto the wound. In all patients, epithelization was complete within 10 (mean: 9) days after the surgery. All patients were followed up for more than 6 months and showed neither depigmentation due to scar formation nor hypertrophic scars. In some patients, some pebbly regrowth had occurred at 5 years postoperatively, but the appearance was quite acceptable.
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| http://dx.doi.org/10.1097/01.sap.0000221621.34715.21 | DOI Listing |
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