The practice of science usually involves more than a solitary genius in a solitary room, coping with the problem of her/his life. From the second half of the 19th century onwards, scientific research, especially in the field of the Natural Sciences, has grown into a more and more complex practice, which often entangles very special needs, in terms of research objects, techniques, sources, and perspectives. A few special places, such as the Stazione Zoologica di Napoli, have represented in this period the focal points of an ever growing international scientific network, promoting independent research, exchange and diffusion of novel practices and techniques and unrestricted confrontation. The so-called "Naples experience" has been cited by a large number of renowned scientists of the last two centuries as a key moment in their scientific life. Here we have tried to test it against the experience of three great scientists par excellence, i.e. three Nobel laureates (T. H. Morgan, Otto Warburg, J. D. Watson). The different experiences they have had at Naples represent, in our view, three different moments of the professional life of almost every scientist. Therefore, we have chosen to present them as a phenomenology. The final section is dedicated to a survey of the Zoological Station's contribution to neurosciences, especially to the Naples experience of the Nobel Prize winner Sir Bernard Katz and his assistant Ricardo Miledi, between 1965 and 1970. Their work on the squid at Naples allowed probing and quantitative refinement of results already obtained on different animals and contributed to reinforce the long lasting neurophysiological tradition of the institute.
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Account Res
December 2024
College of Petroleum Engineering and Geosciences, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.
Background: Since the advent of online research metrics, which began with Web of Science in 1997, these metrics have been increasingly used to rank researchers and universities. Over the last two decades, the easy access to research metrics has greatly benefitted the academic community and beyond by providing quantitative measures for ranking researchers, universities and departments. However, this accessibility, accompanied by a tendency to quantitatively evaluate research quality and impact, has also shifted the focus toward practices aimed at enhancing research metrics rather than pursuing high-quality, potentially path-breaking research.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
December 2024
Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625, Hannover, Germany.
Naunyn-Schmiedeberg's Archives of Pharmacology, founded in 1873, is the oldest pharmacological journal. This study sheds light on the influence of persecution and expulsion of Jewish and dissident German pharmacologists during the Nazi era (1933-1945) on their scientific work and publication behaviour. The analysis is based on the German-language book 'Verfolgte deutschsprachige Pharmakologen (persecuted German-speaking pharmacologists) 1933-1945' by Trendelenburg and Löffelholz (2008), which contains short biographies of 71 persecuted pharmacologists.
View Article and Find Full Text PDFJ Nat Prod
December 2024
Department of Entomology, Cornell AgriTech, Cornell University, Geneva, New York 14456, United States.
The common milkweed is widespread in North America and produces cardenolide toxins that deter herbivores by targeting the transmembrane enzyme Na/K-ATPase. In 1979, Nobel Laureate Tadeus Reichstein elucidated the structure of novel cardenolides isolated from roots and proposed structures for several other cardenolides that could not be confirmed. In this study, we investigate the cardenolide composition of seeds, focusing on their abundance and inhibitory potency on the sensitive porcine Na/K-ATPase and that of the highly resistant large milkweed bug, .
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands.
This study offers insights into a paper by the esteemed editor-in-chief, who conducted a bibliometric comparison of Nobel laureates in physiology, medicine, and chemistry to examine the substantial influence these scientists have had on their respective fields (Naunyn-Schmiedeberg's Arch Pharmacol, 397, 2024, 7169-7185). Analyzing metrics such as laureates' nationalities, ages at productivity peaks, H-index, and age-adjusted H-index, the research highlights distinct career patterns among these distinguished scientists. The present study addresses the limitations of traditional metrics, like the H-index, which may undervalue early-career contributions or multidisciplinary impacts due to its focus on cumulative citations.
View Article and Find Full Text PDFRev Esp Cir Ortop Traumatol
November 2024
Investigador, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, España; Investigador, Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Complutense de Madrid, España.
Santiago Ramón y Cajal (1852-1934), a distinguished histologist and Nobel Laureate in Physiology or Medicine in 1906, is considered the father of Neuroscience. However, his legacy also extended to the study of various tissues, including hyaline cartilage, an area in which he was a pioneer. Throughout his work Elements of Normal Histology and Micrographic Technique, Cajal developed fundamental concepts that, when reviewed in light of molecular biology, resonate with current ideas about cellular communication and macromolecular interactions.
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