Fifteen new betulinic acid analogues were designed, synthesized, and tested for anti-inflammatory activity. Many of these analogues effectively suppress nitric oxide (NO) production in RAW cells stimulated with interferon-gamma. Analogue 10 is highly and orally active in vivo for induction of the anti-inflammatory and cytoprotective enzyme, heme oxygenase-1.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950140 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2006.09.012 | DOI Listing |
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