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Evidence for targeting autonomic dysfunction in systemic sclerosis: A scoping review.
J Scleroderma Relat Disord
January 2025
Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
Autonomic dysfunction is a common and early complication among patients with systemic sclerosis, suggesting that it may play a role in the pathogenesis of the disease and be a potential target for therapeutic interventions. Although the true prevalence of autonomic dysfunction among patients with systemic sclerosis is still unclear, it is estimated that as many as 80% of patients may be affected. Autonomic dysfunction may lead to widespread multi-organ dysfunction through its effects on the cardiovascular system, gastrointestinal tract, urinary tract, sweat and salivary glands, and pupils.
View Article and Find Full Text PDFThe Role of Empiric Antifungal Therapy in Patients With Perforated Peptic Ulcer: An Updated Systematic Review and Meta-Analysis.
Am Surg
January 2025
Department of Surgery, Division of Acute Care Surgery and Surgical Critical Care, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Fungal growth is common in intraoperative cultures of patients with perforated peptic ulcer (PPU) leading to the common use of empiric antifungal therapy, with current evidence not clearly supporting this practice. The goal of this updated systematic review and meta-analysis was to synthesize the effect of empiric antifungals in patients with PPU. Eligible studies were identified through a comprehensive literature search in the MEDLINE (PubMed) and EMBASE databases, following the PRISMA 2020 statement.
View Article and Find Full Text PDFHigh Rate of Return to Sport for Athletes Undergoing Articular Cartilage Restoration Procedures for the Knee: A Systematic Review of Contemporary Studies.
Am J Sports Med
January 2025
Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York, USA.
Background: Continued advancements in cartilage surgery and an accumulating body of evidence warrants a contemporary synthesis of return to sport (RTS) outcomes to provide updated prognostic data and to better understand treatment response.
Purpose: To perform an updated systematic review of RTS in athletes after knee cartilage restoration surgery.
Study Design: Systematic review; Level of evidence, 4.
Evolving trends in novel sleep tracking and sleep testing technology publications between 2020-2022.
J Clin Sleep Med
January 2025
Indiana University School of Medicine, Indianapolis, Indiana.
Study Objectives: To update sleep medicine providers regarding (1) published research on the uses and performance of novel sleep tracking and testing technologies (2) the use of artificial intelligence to acquire and process sleep data and (3) research trends and gaps regarding the development and/or evaluation of these technologies.
Methods: Medline and Embase electronic databases were searched for studies utilizing screening and diagnostic sleep technologies, published between 2020 and 2022 in journals focusing on human sleep. Studies' quality was determined based on the Study Design criteria of The Oxford Centre for Evidence-Based Medicine Levels of Evidence.
Barriers and Enablers of Primary Healthcare Professionals in Health Research Engagement: A Systematic Review of Qualitative Studies.
Nurs Health Sci
March 2025
Faculty of Medicine Nursing and Health Science, Monash University, Melbourne, Victoria, Australia.
Health professional engagement ensures relevant, clinically focused research that informs evidence-based care. Research shows health professionals may not engage optimally in research. Understanding barriers and enablers influencing participation is necessary to enhance engagement.
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