AI Article Synopsis
- CD14 is believed to have a role in immunity and damage caused by chlamydial infections, though its function in mice was previously unexplored.
- Female mice lacking the CD14 gene and wild type mice were infected with Chlamydia muridarum, and their infections were monitored using swabs.
- The CD14 knockout mice cleared the infection more quickly, but both groups experienced hydrosalpinx formation at similar rates, indicating CD14 affects infection but not related infertility outcomes.
Article Abstract
Background: CD14 has been postulated to play a role in chlamydial immunity and immunopathology. There is evidence to support this role in human infections but its function in a mouse model has not been investigated.
Methods: Female CD14 gene knockout and C57BL/6J wild type mice were infected intravaginally with Chlamydia muridarum. The infection course was monitored by detection of viable chlamydiae from serially collected cervical-vaginal swabs. The sequela of tubal factor infertility was assessed using hydrosalpinx formation as a surrogate marker.
Results: A significantly abbreviated infection course was observed in the CD14 gene knockout mice but hydrosalpinx formation occurred at similar rates between the two groups.
Conclusion: Involvement of CD14 during chlamydial infection impedes infection resolution but this does not affect the sequela of infertility as assessed by hydrosalpinx formation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1590040 | PMC |
| http://dx.doi.org/10.1186/1471-2334-6-144 | DOI Listing |
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