AI Article Synopsis
- A new approach is introduced for creating racemic 1-nitroalkan-2-ols by reacting bromonitromethane with different aldehydes using SmI2 as a catalyst.
- This method also allows for the synthesis of chiral compounds using chiral N,N-dibenzyl amino aldehydes.
- The process yields enantiopure 3-amino-1-nitroalkan-2-ols with high selectivity for their stereochemistry.
Article Abstract
A novel method to obtain racemic 1-nitroalkan-2-ols by reaction of bromonitromethane with a variety of aldehydes and promoted by SmI2 is reported. On the basis of these results, the chiral version has also been performed with chiral N,N-dibenzyl amino aldehydes, affording the corresponding enantiopure 3-amino-1-nitroalkan-2-ols with good stereoselectivity.
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Article Synopsis
- A new approach is introduced for creating racemic 1-nitroalkan-2-ols by reacting bromonitromethane with different aldehydes using SmI2 as a catalyst.
- This method also allows for the synthesis of chiral compounds using chiral N,N-dibenzyl amino aldehydes.
- The process yields enantiopure 3-amino-1-nitroalkan-2-ols with high selectivity for their stereochemistry.
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