Three new epipolythiodioxopiperazines, chaetocochins A (1), B (2), and C (3), along with dethio-tetra (methylthio) chetomin (4) and chetomin (5), were isolated from the ethyl acetate extract of the solid-state fermented rice culture of the fungus Chaetomium cochliodes. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1, 3, and 4 exhibited significant cytotoxicity in vitro against cancer cell lines Bre-04, Lu-04, and N-04.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np0602970 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioprospecting Endophytic Fungi of Forest Plants for Bioactive Metabolites with Antibacterial, Antifungal, and Antioxidant Potentials.
Molecules
October 2024
Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
The growing emergence of multi-drug resistant microbial strains has kept the scientific world searching for novel bioactive compounds with specific chemical characteristics. Accordingly, researchers have started exploring the understudied metabolites from endophytes as a new source of bioactive compounds. In this context, the current study was designed to evaluate the bioactive properties of endophytic fungi from the Mokrzański forest in Wrocław, Poland that have not yet been fully researched.
View Article and Find Full Text PDFUPLC-Q-TOF-MS/MS-Based Targeted Discovery of Chetomin Analogues from .
J Nat Prod
June 2024
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
Chetocochliodin M () containing a rare cage-ring and chetocochliodin N () featuring an unusual piperazine-2,3-dione ring system together with known analogues chetomin (), chetoseminudin C (), chetocochliodin I (), and oidioperazine E () were targeted for purification from the fungus using a UPLC-Q-TOF-MS/MS approach. The structures of the new compounds were elucidated using HR-ESI-MS, NMR, and ECD spectra. Compounds , , and exhibited strong cytotoxic activities against A549 and HeLa cancer cell lines.
View Article and Find Full Text PDFReconstitution of the Early Stage of Chetomin Biosynthesis in Leads to the Production of Epipolythiodioxopiperazines.
Org Lett
May 2024
Department of Microbiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, People's Republic of China.
Using CRISPR-Cas9 technology and a microhomology-mediated end-joining repair system, we substituted genes of the gliotoxin pathway in with genes responsible for chetomin biosynthesis from , leading to the production of three new epipolythiodioxopiperazines (ETPs). This work represents the first successful endeavor to produce ETPs in a non-native host. Additionally, the simultaneous disruption of five genes in a single transformation marks the most extensive gene knockout event in filamentous fungi to date.
View Article and Find Full Text PDFComposition of Culturable Microorganisms in Dusts Collected from Sport Facilities in Finland during the COVID-19 Pandemic.
Pathogens
February 2023
Department of Civil Engineering, School of Engineering, Aalto University, P.O. Box 12100, FI-00076 Aalto, Finland.
Sport facilities represent extreme indoor environments due to intense cleaning and disinfection. The aim of this study was to describe the composition of the cultivated microbiota in dust samples collected in sport facilities during the COVID-19 pandemic. A dust sample is defined as the airborne dust sedimented on 0.
View Article and Find Full Text PDFWas the Dominant Genus Found during Diversity Tracking of Potentially Pathogenic Indoor Fungal Isolates.
Pathogens
October 2022
Department of Civil Engineering, Aalto University, FI-00076 Aalto, Finland.
Viable airborne pathogenic fungi represent a potential health hazard when exposing vulnerable persons in quantities exceeding their resilience. In this study, 284 indoor fungal isolates from a strain collection of indoor fungi were screened for pathogenic potential through the ability to grow in neutral pH at 37 °C and 30 °C. The isolates were collected from 20 locations including 14 problematic and 6 non-problematic ordinary buildings.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!