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Current trends in plague research: from genomics to virulence. | LitMetric

Current trends in plague research: from genomics to virulence.

Clin Med Res

Division of Communicable Immunology, Department of Bacterial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Published: September 2006

Yersinia pestis is the causative agent of plague, which diverged from Yersinia pseudotuberculosis within the past 20,000 years. Although these two species share a high degree of homology at the DNA level (>90%), they differ radically in their pathogenicity and transmission. In this review, we briefly outline the known virulence factors that differentiate these two species and emphasize genetic studies that have been conducted comparing Y. pestis and Y. pseudotuberculosis. These comparisons have led to a better understanding of the genetic contributions to the differences in the virulence and pathogenicity between these two organisms and have generated information that can be applied in future diagnostic and vaccine development. Comparison of the genetic differences between Y. pestis and Y. pseudotuberculosis has also lent insight into the emergence of acute pathogens from organisms causing milder diseases.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570480PMC
http://dx.doi.org/10.3121/cmr.4.3.189DOI Listing

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