AI Article Synopsis
- The study demonstrated that chiral dendritic catalysts made from N-prolylsulfonamide efficiently catalyze direct aldol reactions in water, producing high yields (up to 99%).
- These reactions showed remarkable anti diastereoselectivity (over 99:1) and enantioselectivity (over 99% ee).
- The catalyst was recoverable through precipitation and filtration, allowing for reuse in up to five cycles without losing effectiveness.
Article Abstract
The direct aldol reactions catalyzed by chiral dendritic catalysts derived from N-prolylsulfonamide gave the corresponding products in high isolated yields (up to 99%) with excellent anti diastereoselectivities (up to >99:1) and enantioselectivities (up to >99% ee) in water. In addition, catalyst 1e may be recovered by precipitation and filtration and reused for at least five times without loss of catalytic activity.
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| http://dx.doi.org/10.1021/ol061418q | DOI Listing |
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