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Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia: A Secondary Analysis of 4 Randomized Clinical Trials.
JAMA Netw Open
November 2024
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.
Article Synopsis
- MDMA (ecstasy) is being studied as a treatment for PTSD but has the risk of causing low sodium levels (hyponatremia) after just one dose due to factors like vasopressin release and excessive drinking.
- This study aimed to analyze how often and severely hyponatremia occurs after a single MDMA dose, looking at underlying hormonal mechanisms and whether limiting fluid intake could reduce this risk.
- Out of 96 participants, about 31% experienced hyponatremia, but none in the group with fluid restrictions, suggesting that managing fluid intake could lessen the chance of developing this complication.
Rave gone wrong: MDMA- induced medical emergency at electrical daisy carnival. A case report.
Toxicol Rep
December 2024
Kirk Kerkorian School of Medicine at UNLV, Department of Internal Medicine, 625 Shadow Lane, Las Vegas 89106, USA.
Article Synopsis
- A 35-year-old male suffered a life-threatening overdose at the festival, experiencing seizures and hyperthermia, leading to his emergency intubation and treatment for multiple organ failure.
- The case emphasizes the need for quick medical intervention to save lives after MDMA overdoses and highlights the importance of raising awareness about the risks associated with using this drug at music events.
Behavioral metabolomics: how behavioral data can guide metabolomics research on neuropsychiatric disorders.
Metabolomics
August 2023
School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
Introduction: Metabolomics produces vast quantities of data but determining which metabolites are the most relevant to the disease or disorder of interest can be challenging.
Objectives: This study sought to demonstrate how behavioral models of psychiatric disorders can be combined with metabolomics research to overcome this limitation.
Methods: We designed a preclinical, untargeted metabolomics procedure, that focuses on the determination of central metabolites relevant to substance use disorders that are (a) associated with changes in behavior produced by acute drug exposure and (b) impacted by repeated drug exposure.
Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity.
Biomed Pharmacother
August 2023
Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. Electronic address:
3,4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug, however over 200 studies demonstrate that acute (e.g. hyperthermia, rhabdomyolysis) and chronic (e.
View Article and Find Full Text PDFWithania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice.
Biomed Pharmacother
May 2023
Department of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Cagliari, Italy; National Research Council of Italy, Neuroscience Institute, Cagliari, Italy.
Withania somnifera (WS) is utilized in Ayurvedic medicine owing to its central and peripheral beneficial properties. Several studies have accrued indicating that the recreational amphetamine-related drug (+/-)- 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) targets the nigrostriatal dopaminergic system in mice, inducing neurodegeneration and gliosis, causing acute hyperthermia and cognitive impairment. This study aimed to investigate the effect of a standardized extract of W.
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