The effect of a single teratogenic dose of the antiepileptic drug valproic acid and its nonteratogenic metabolite, 2-en-valproic acid, on zinc concentrations in mouse plasma, embryo, and decidua on d 9 of gestation was investigated. The substances were injected subcutaneously (sc) as their sodium salts. In this mouse model, valproic acid induced between 20% (400 mg/kg dose) and 60% (600 mg/kg dose) incidence of exencephaly in living fetuses; 2-en-valproic acid was not teratogenic at these dose levels. The zinc concentrations in plasma were significantly increased 1 and 2 h after administration of both substances. The embryonic zinc concentrations were increased 2 and 4 h after application of both substances. The concentrations of zinc in the decidua were not affected. The similarity of effects of valproic acid and its nonteratogenic analog on zinc concentrations in maternal plasma and embryo suggests that the teratogenicity of a single administration of valproic acid in the mouse is not owing to interference with the zinc metabolism in this species.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF02990416 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Global transcriptional modulation and nutritional status of soybean plants following foliar application of zinc borate as a suspension concentrate fertilizer.
Sci Rep
January 2025
School of Agriculture and Food Systems, Davis College of Agriculture and Natural Resources, West Virginia University, Morgantown, WV, USA.
The management of micronutrients, such as boron (B) and zinc (Zn), is critical for plant growth and crop yields. One method of rapid intervention crop management to mitigate nutritional deficiency is the foliar supply of B and Zn. Our study investigates the effect of foliar-supplied B and Zn availability on the global transcriptional modulation in soybean (Glycine max).
View Article and Find Full Text PDFHidden Threat in Turbid Waters: Quantifying and Modeling the Bioaccumulation and Risks of Particulate Metals to Clams.
Environ Pollut
January 2025
Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, State Key Lab of Marine Environmental Science, College of the Environment and Ecology, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:
A major proportion of metal contaminants in aquatic environments is bound to suspended particulate matter (SPM), yet environmental monitoring typically focuses on dissolved metals, with the filtration step removing SPM. This step may inadvertently hide the potential risks posed by particulate metals. In this study, we used stable isotope tracers to quantify the contributions of SPM-bound metals to the bioaccumulation of nickel (Ni), copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) in Ruditapes philippinarum, a widely distributed clam crucial to global aquaculture.
View Article and Find Full Text PDFRole of zinc homeostasis in the prevention of prostate diseases.
J Trace Elem Med Biol
January 2025
Graduate School of Hebei Medical University, Shijiazhuang, Hebei 050017, China; Hebei General Hospital, Shijiazhuang, Hebei 050051, China. Electronic address:
The prostate gland is the largest accessory sex gland in the male reproductive system, and is recognized for its elevated zinc concentration. Recently, the incidence of prostate diseases has increased, posing a significant threat to the health of men. Increasing evidence suggests that maintaining normal prostate function requires proper zinc homeostasis.
View Article and Find Full Text PDFEvaluation of Heavy Metal Contamination from Large-scale Swine-Farming Wastewater in Sichuan Province, China: Removal Efficiency, Spatial Distribution and Risk Assessment.
Bull Environ Contam Toxicol
January 2025
Sichuan Academy of Eco-Environmental Sciences, Chengdu, 610041, China.
The widespread application of swine-farming wastewater to soil and water is increasingly contributing to heavy metal contamination, posing significant environmental risks. This study investigated the concentrations of eight heavy metals in swine-farming wastewater following different treatment processes, and assessed their ecological risks in Sichuan Province, China. The findings revealed that zinc, copper and nickel exhibited the highest concentrations, potentially causing heavy or strong contamination levels and leading to heavy or slight ecological risks.
View Article and Find Full Text PDFModulation of Zn Ion Toxicity in L. by Phycoremediation.
Plants (Basel)
January 2025
Department of Plant Physiology, Faculty of Biology, Sofia University, 8 Dragan Tsankov Bul., 1164 Sofia, Bulgaria.
Microalgae offer a promising alternative for heavy metal removal, and the search for highly efficient strains is ongoing. This study investigated the potential of two microalgae, sp. BGV (Chlorophyta) and Schwabe & Simonsen (Cyanoprokaryota), to bind zinc ions (Zn⁺) and protect higher plants.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!