AI Article Synopsis
- Gene therapy is a promising treatment option for various diseases, enabling the manipulation of DNA to correct, enhance, or activate genes and immune responses.
- It shows significant potential against cancer, with successful results observed in animal studies leading to experimental applications in humans.
- The review focuses on gene therapy's role in cervical cancer, particularly how it addresses immune system changes in the tumor micro-environment and utilizes cytokines as immunomodulators.
Article Abstract
Gene therapy is an excellent alternative for treatment of many diseases. Capacity to manipulate the DNA has allowed direct the gene therapy to correct the function of an altered gene, to increase the expression of a gene and to favour the activation of the immune response. This way, it can intend the use of the DNA like medication able to control, to correct or to cure many diseases. Gene therapy against cancer has an enormous potential, and actually the use of the DNA has increased to control diverse cancer in animal models, with very encouraging results that have allowed its applications in experimental protocols in human. This work concentrates a review of the foundations of the gene therapy and its application on cervical cancer, from the point of view of the alterations of the immune system focused on the tumour micro-environment, and the use of the cytokines as immunomodulators.
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| http://dx.doi.org/10.1590/s0036-36342005000600011 | DOI Listing |
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