Available information regarding the clinical features of cannabis-induced psychoses among schizophrenia patients is rather odd and even discrepant. For thorough investigation psychopathology due to marijuana intoxication, we examine two groups of schizophrenia patients. I group--14 patients, who had long history of cannabis use before developing schizophrenia, and II group--schizophrenic patients, who already had schizophrenia and later became marijuana users. Clinical study allowed us to determine the general psychopathological symptoms due to acute intoxication on the one hand, reflecting duration and severity of intoxication, and let us to verify specific mental problems connected to the dynamics of schizophrenia, on the other hand. Peculiar properties of the data of the experimental-psychological tests TAT (Thematic Apperception Test) reflect personality changes generated by schizophrenia progression included the psychopathological phenomenon related to cannabis intoxication. Psychopharmacological treatment brought positive changes in structure and thematic features of the data. The patients used more words. The content and the volume of the stories increased. Trends to improvement were more common for recurrent rather than continuous duration of schizophrenia.
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Cureus
December 2024
Department of Psychiatry, Texas Tech University Health Sciences Center, Odessa, USA.
Schizophrenia is a chronic psychiatric disorder with a complex etiology involving genetic, neurobiological, and environmental factors. Many individuals with schizophrenia experience treatment resistance despite advances in pharmacologic and non-pharmacologic interventions. Immune dysregulation, characterized by altered cytokine levels, immune-related gene expression, and neuroinflammation, plays a critical role in schizophrenia's pathogenesis.
View Article and Find Full Text PDFJ Intellect Dev Disabil
June 2024
Department of Developmental Psychiatry, Institute of Mental Health, Singapore.
Background: People with an intellectual disability have a higher risk of developing mental disorders compared to the general population. Available evidence suggests those with an intellectual disability receiving inpatient treatment in general psychiatric wards may have certain unique characteristics.
Method: Data gathered from a retrospective review of records of adults with intellectual disability admitted to general psychiatry wards in a tertiary psychiatric hospital in Singapore were analysed.
Psychiatry Clin Neurosci
January 2025
Department of Radiology, and Functional and Molecular Imaging key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Aim: As a central component of schizophrenia psychopathology, negative symptoms result in detrimental effects on long-term functional prognosis. However, the neurobiological mechanism underlying negative symptoms remains poorly understood, which limits the development of novel treatment interventions. This study aimed to identify the specific neural fingerprints of negative symptoms in schizophrenia.
View Article and Find Full Text PDFSci Rep
January 2025
Laboratory of Neurolinguistics and Experimental Pragmatics (NEP), University School for Advanced Studies IUSS, Piazza della Vittoria 15, Pavia, 27100, Italy.
Physical Restraint (PR) is a coercive procedure used in emergency psychiatric care to ensure safety in life-threatening situations. Because of its traumatic nature, studies emphasize the importance of considering the patient's subjective experience. We pursued this aim by overcoming classic qualitative approaches and innovatively applying a multilayered semiautomated language analysis to a corpus of narratives about PR collected from 99 individuals across seven mental health services in Italy.
View Article and Find Full Text PDFSchizophrenia (Heidelb)
January 2025
Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, WA, USA.
In West Africa, the long-term consequences of poor early psychosis recovery include poverty, neglect, and community ostracization. To understand the potential for digital health approaches to support early psychosis care in Ghana, we conducted a survey study among early psychosis patients and their caregivers about mental health needs, technology use and access, and interest in digital mental health. Hospital staff at Accra Psychiatric Hospital reviewed hospital medical records from January 2023 - December 2023 identifying young adults (≥18 years old) who had experienced psychosis symptoms for the first time within the prior five years.
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