We have done retrospective analysis of stillbirth. The aim of our study was to investigate specific role of infections in stillbirth on the basis of archival data of Acad. Chachava Research Institute of Perinatal Medicine, Obstetrics and Gynecology. In 768 cases of stillbirth over a period 2000-2004, in 591 cases occurred intrauterine fetal death (IFD) (77%). In 85% of cases it was related to the preterm labor. Most frequently IFD occurred in relation to the congenital fetal malformations (24.4%). In 12.1% of cases the cause of the structural anomalies in fetuses was unknown. Infectious pathology occurred in 17.1% of cases and in 15.4%--preeclampsia. Significantly high percent are related to the unknown reasons that lead to the IFD (34.3%). Study addressing the risk factors of the intrauterine fetal death IFD revealed that odds ratio (OR) is the most high for fetal malformation--36.34; for preeclampsia--5.15; for infectious pathology--10.93; so it holds the third place after the fetal maldevelopment and preeclampsia.
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Curr Nutr Rep
January 2025
Department of Nutrition and Dietetics, Gazi University, Ankara, Türkiye.
Purpose Of Review: The aim of this review is to summarize and put into context the current evidence on anthropometric measurements and laboratory methods used in the evaluation of body composition in pregnancy, in the light of current studies.
Recent Findings: Protecting women's health during pregnancy, childbirth and the postnatal period is important for maternal health. Pregnancy is a critical period during which the female body undergoes significant changes to support fetal growth and development.
Postgrad Med J
January 2025
Saint Louis University, Department of Gastroenterology, 1 N Grand Blvd, St. Louis, MO, 63103, United States.
Introduction: Diabetes Mellitus (DM) affects both the mother and fetus during and after pregnancy. Multiple studies have shown the prognostic impact of DM on maternal and fetal outcomes, but studies at the national level are limited. Therefore, we aimed to conduct this nationwide study.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Obstetrics and Gynecology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Pregnancy complications associated with thrombophilia represent significant risks for maternal and fetal health, leading to adverse outcomes such as pre-eclampsia, recurrent pregnancy loss, and intra-uterine growth restriction (IUGR). They are caused by disruptions in key physiological processes, including the coagulation cascade, trophoblast invasion, angiogenesis, and immune control. Recent advancements in epigenetics have revealed that non-coding RNAs, especially microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and extracellular vesicles (EVs) carrying these RNAs, play crucial roles in the regulation of these biological processes.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Laboratory of Comparative Developmental Physiology, Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 119334 Moscow, Russia.
Available evidence from animal studies suggests that placental serotonin plays an important role in proper fetal development and programming by altering brain circuit formation, which later translates into altered abnormal adult behaviors. Several environmental stimuli, including stress and maternal inflammation, affect placental and, hence, fetal serotonin levels and thus may disturb fetal brain development. We investigated the effect of prenatal stress of varying intensities on the formation of adaptive behaviors in mouse offspring and the role of placental serotonin in these processes.
View Article and Find Full Text PDFLife (Basel)
December 2024
Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.
Infants born with intrauterine growth restriction (IUGR) have up to a five-fold higher risk of learning and memory impairment than those with normal growth. Using a mouse model of hypertensive diseases of pregnancy (HDP) to replicate uteroplacental insufficiency (UPI), we have previously shown that UPI causes premature embryonic hippocampal dentate gyrus (DG) neurogenesis in IUGR offspring. The DG is a brain region that receives the first cortical information for memory formation.
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