The Réseau de recherche sur le cancer (RR-cancer) a unit of the Fonds de la recherche en santé du Québec (FRSQ) has joined the worldwide effort to uncover mechanisms involved in cancer development through its well established clinical and fundamental research units. Encouraged by the excellence of the Quebec research community, the RR-cancer has developed a specialized infrastructure which allows better access to tissues and to state of the art analysis services. The research is founded on four axes: 1) Database and Tissue Bank; 2) Leukaemia cell bank; 3) Experimental therapy and 4) the Oncological Research Group of Québec. With these programs, the RR-cancer contributes to ameliorating prevention, diagnosis and treatment of cancer by facilitating access to the highest quality research material. Optimization of resources is made possible by the contributions of basic scientists and clinicians working together towards a unified objective: fighting cancer.
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Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon.
Commun Biol
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Institute of Phytopathology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392, Giessen, Germany.
In vertebrates and plants, dsRNA plays crucial roles as PAMP and as a mediator of RNAi. How higher fungi respond to dsRNA is not known. We demonstrate that Magnaporthe oryzae (Mo), a globally significant crop pathogen, internalizes dsRNA across a broad size range of 21 to about 3000 bp.
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Sci Data
January 2025
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
As the occurrence of human diseases and conditions increase, questions continue to arise about their linkages to chemical exposure, especially for per-and polyfluoroalkyl substances (PFAS). Currently, many chemicals of concern have limited experimental information available for their use in analytical assessments. Here, we aim to increase this knowledge by providing the scientific community with multidimensional characteristics for 175 PFAS and their resulting 281 ion types.
View Article and Find Full Text PDFMathematical model linking telomeres to senescence in Saccharomyces cerevisiae reveals cell lineage versus population dynamics.
Nat Commun
January 2025
Sorbonne Université, CNRS, Laboratory of Computational and Quantitative Biology, LCQB, Paris, France.
Telomere shortening ultimately causes replicative senescence. However, identifying the mechanisms driving replicative senescence in cell populations is challenging due to the heterogeneity of telomere lengths and the asynchrony of senescence onset. Here, we present a mathematical model of telomere shortening and replicative senescence in Saccharomyces cerevisiae which is quantitatively calibrated and validated using data of telomerase-deficient single cells.
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Faculté de Médecine Paris-Saclay, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France.
Genetically attenuated parasites show promise as a next-generation malaria vaccine.
Trends Parasitol
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Department of Molecular Parasitology, Institute of Biology, Humboldt Universität zu Berlin, 10115 Berlin, Germany. Electronic address:
Metabolically active, genetically attenuated Plasmodium falciparum parasite lines are promising second-generation malaria vaccine candidates. Lamers et al. and Roozen et al.
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