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Leptomeningeal dissemination in H3 K27M- mutant diffuse midline gliomas: clinical characteristics, risk factors, and prognostic insights.
J Neurooncol
January 2025
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, China.
Purpose: This study aimed to describe the incidence, clinical and pathological features, and outcomes of H3 K27M- mutant Diffuse Midline Glioma (DMG) patients with leptomeningeal dissemination (LMD) and systematically investigate the predictive and prognostic factors to clarify the response to treatment after the onset of LMD.
Methods: A total of 304 patients diagnosed with DMG from October 17, 2017, to October 17, 2023, were enrolled in this study, of which 32 patients were diagnosed with LMD. Logistic regression analyses were conducted to identify the predictors of LMD, including clinical, molecular, and imaging data.
Cost efficiency of inpatient rehabilitation following acquired brain injury: the first international adaptation of the UK approach.
BMJ Open
December 2024
Regional Rehabilitation Unit, Northwick Park Hospital, London, UK.
Objectives: To adapt and apply a model for evaluating the functional benefits and cost efficiency of specialist inpatient rehabilitation to the Australian context, comparing functional outcomes and savings in the cost of ongoing care after acquired brain injury.
Design: An observational cohort analysis of prospectively collected clinical data from admission to discharge, with follow-up to 3 years.
Setting: A newly established state-wide inpatient postacute rehabilitation unit in Victoria, Australia for patients with moderate to severe acquired brain injury.
[Establishing and implementing the National Action Plan Health Literacy in Germany].
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
January 2025
Hertie School - University of Governance, Berlin, Deutschland.
About ten years ago, studies on health literacy in Germany indicated that population health literacy was low. This prompted a group of distinguished experts to initiate the development of a National Action Plan for Health Literacy (NAP-HL) for Germany, modeled after those of other countries. This article explains the origins and development of the plan in Germany, provides an overview of the steps taken during its creation, and summarizes its content.
View Article and Find Full Text PDFCongress of Neurological Surgeons systematic review and evidence-based guidelines for the role of surgery in the management of patients with diffuse low grade glioma: update.
J Neurooncol
January 2025
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
Target populationAdults with imaging suggestive of a WHO grade II diffuse gliomas (oligodendrogliomas or astrocytomas)QuestionIn adults with imaging suggestive of a WHO grade II diffuse gliomas (oligodendrogliomas or astrocytomas), does surgical resection improve overall survival compared to observation or biopsy?Updated Recommendation from the Prior Version of These Guidelines:Level III: In adults with imaging suggestive of a WHO grade II diffuse gliomas (oligodendrogliomas or astrocytomas), surgical resection is suggested over observation or biopsy to improve overall survival.Question Q2In adults with imaging suggestive of a WHO grade II diffuse gliomas (oligodendrogliomas or astrocytomas), does maximal surgical resection improve progression free survival (PFS) and overall survival (OS) compared to subtotal resection/biopsy?Unchanged Recommendations from the Prior Version of These GuidelinesLevel II It is recommended that GTR or STR be accomplished instead of biopsy alone when safe and feasible so as to decrease the frequency of tumor progression recognizing that the rate of progression after GTR is fairly high.Level III Greater extent of resection can improve OS in WHO grade II diffuse gliomas patients.
View Article and Find Full Text PDFBlastomycosis of the scrotum: Not a fun guy.
Urol Case Rep
January 2025
Lakeridge Health Oshawa, Hospital Ct, Oshawa, ON, L1G 8A2, Canada.
is a fungal pathogen endemic to North America. Infection from inhalation of its conidia has diffuse clinical manifestations. These can include genitourinary system infections which may manifest as ulcerative, draining skin lesions.
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