A practical method, based on depth dose, for determining organ dose during computed tomography (CT) examination is presented. For 4-slice spiral CT scans, performed at radii of 0, 37.5, 75.0, 112.5, and 150.0 mm, measurement of depth dose has been made using thermoluminescent dosimeters (TLDs) inserted into a modified International Electrotechnical Commission (IEC) standard dosimetry phantom and also additional TLDs placed on the surface of the phantom. A regression equation-linking dose with distance from the center of the phantom has been formulated, from which dose to a point of interest relative to the surface dose can also be calculated. The approximation reflects the attenuation properties of X-rays in the phantom. Using the equation, an estimate of organ dose can be ascertained for CT examination, assuming water equivalence of human tissue and a known organ position and volume. Using the 4-slice spiral scanner, relative doses to a patients' lung have been calculated, the location and size of the lung in vivo being found from the CT scan image, and the lung being divided into 38 segments to calculate the relative dose. Results from our test case show the dose to the lung to have been 69+/-13% of surface dose.
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http://dx.doi.org/10.1016/j.apradiso.2006.07.007 | DOI Listing |
Cureus
December 2024
Department of Diagnostic Imaging and Radiotherapy, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan Campus, Kuantan, MYS.
In abdominal X-ray examinations, radiosensitive organs such as the gonads within or near the imaging region are at risk of radiation exposure. Minimizing the dose to these organs is crucial to reducing unnecessary radiation. This study utilized optically stimulated luminescence dosimeters (OSLDs) to measure the radiation dose to the male gonads at varying kilovoltage peak (kVp) settings while keeping the milliampere-seconds (mAs) constant across different radiographic projections.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Heat Stroke Treatment and Research Center of Chinese PLA General Hospital, Sanya, China.
Exertional heat stroke (EHS) is a life-threatening condition characterized by hyperthermia and multi-organ dysfunction, often associated with intestinal barrier disruption. This study evaluated the protective effects of Huoxiang Zhengqi Dropping Pills (HXZQD) against EHS in a rat model. HXZQD was administered via oral gavage at low, medium, and high doses, followed by EHS induction through exercise under high-temperature and high-humidity conditions.
View Article and Find Full Text PDFEur Heart J Case Rep
January 2025
Cardiology Department, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60153-3328, USA.
Background: Immune checkpoint inhibitors (ICIs) are effective antineoplastic agents but can cause adverse effects in many organ systems. Cardiovascular toxicities include arrhythmias, myocarditis, heart failure, takotsubo syndrome, pericarditis, coronary artery disease, and vasculitis.
Case Summary: A 66-year-old woman with Stage 3C2 endometrial carcinoma presented for her second cycle of pembrolizumab, carboplatin, and paclitaxel.
Phys Imaging Radiat Oncol
January 2025
Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.
Background And Purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose. However, RBE varies with tissue type, fraction dose, and beam quality parameters beyond dose such as linear energy transfer (LET) raising concerns about increased local effectiveness and potential toxicity.
View Article and Find Full Text PDFFront Oncol
January 2025
Department of Clinical Development, POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company, Indianapolis, IN, United States.
Introduction: SPLASH (NCT04647526) is a multicenter phase III trial evaluating the efficacy and safety of [Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC). This study leveraged a lead-in phase to assess tissue dosimetry and evaluate preliminary safety and efficacy, prior to expansion into a randomized phase. Here we report those results.
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