A new approach is suggested for evaluation of changes observed in serum levels of immunoglobulins, compliment components and proteinase inhibitors in subjects suffering from chronic obstructive bronchitis (COB). These levels were compared for COB patients (n-15) in remission and under aggravation of the disease. The comparison promoted a significant assessment of the shifts and their pattern for humoral defence factors. There appeared a correlation between concentration of some serum proteins and bronchial obstruction characteristics.
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