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Rosai-Dorfmann Disease: A Rare Disease Presenting as a Unilateral Neck Swelling.
Indian J Otolaryngol Head Neck Surg
February 2024
Department of Otorhinolaryngology, Dr. B R Ambedkar Medical College and Hospital, Kadugondanahalli, Bangalore, Karnataka 560045 India.
Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder of unknown etiology. Usually it presents with massive painless cervical lymph node enlargement. Histologically, it shows proliferation of distinctive histiocytic cells that demonstrate emperipolesis in the background of a mixed inflammatory infiltrates.
View Article and Find Full Text PDFLow respiratory quotient correlates with high mortality in patients undergoing mechanical ventilation.
Am J Emerg Med
April 2024
The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America; Department of Emergency Medicine, Zucker School of Medicine at Hofstra/Northwell, New York, NY, United States of America; Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY, United States of America.
Objective: Oxygen consumption (VO), carbon dioxide generation (VCO), and respiratory quotient (RQ), which is the ratio of VO to VCO, are critical indicators of human metabolism. To seek a link between the patient's metabolism and pathophysiology of critical illness, we investigated the correlation of these values with mortality in critical care patients.
Methods: This was a prospective, observational study conducted at a suburban, quaternary care teaching hospital.
Continuous and repeat metabolic measurements compared between post-cardiothoracic surgery and critical care patients.
BMC Pulm Med
October 2023
The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Objective: Using a system, which accuracy is equivalent to the gold standard Douglas Bag (DB) technique for measuring oxygen consumption (VO), carbon dioxide generation (VCO), and respiratory quotient (RQ), we aimed to continuously measure these metabolic indicators and compare the values between post-cardiothoracic surgery and critical care patients.
Methods: This was a prospective, observational study conducted at a suburban, quaternary care teaching hospital. Age 18 years or older patients who underwent mechanical ventilation were enrolled.
High throughput isolation of RNA from single-cells within an intact tissue for spatial and temporal sequencing a reality.
PLoS One
August 2023
Department of Biomolecular Engineering, University of California, Santa Cruz, California, United States of America.
Single-cell transcriptomics is essential for understanding biological variability among cells in a heterogenous population. Acquiring high-quality single-cell sequencing data from a tissue sample has multiple challenges including isolation of individual cells as well as amplification of the genetic material. Commercially available techniques require the isolation of individual cells from a tissue through extensive manual manipulation before single cell sequence data can be acquired.
View Article and Find Full Text PDFAn Automation System Equivalent to the Douglas Bag Technique Enables Continuous and Repeat Metabolic Measurements in Patients Undergoing Mechanical Ventilation.
Clin Ther
November 2022
The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York; Department of Emergency Medicine, Zucker School of Medicine at Hofstra/Northwell, New York, New York; Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York.
Purpose: To develop a system that is equivalent to the gold standard Douglas Bag (DB) technique for measuring oxygen consumption (V̇o), carbon dioxide generation (V̇co), and respiratory quotient (RQ) and to validate its use in clinical settings.
Methods: This was a prospective, observational study conducted at a suburban, quaternary care teaching hospital. Healthy volunteers and patients 18 years or older who received mechanical ventilation were enrolled.
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