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Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology - A Potential Driver for Reducing/Replacing Laboratory Animals in the Future.
Altern Lab Anim
December 2024
3Rs Management and Consulting ApS, Lyngby, Denmark.
The first ONTOX Hackathon of the EU Horizon 2020-funded ONTOX project was held on 21-23 April 2024 in Utrecht, The Netherlands (https://ontox-project.eu/hackathon/). This participatory event aimed to collectively advance innovation for human safety through the use of Artificial Intelligence (AI), and hence significantly reduce reliance on animal-based testing.
View Article and Find Full Text PDFIn vitro hepatic 3D cell models and their application in genetic toxicology: A systematic review.
Mutat Res Genet Toxicol Environ Mutagen
December 2024
National Institute of Biology, Department of Genetic Toxicology and Cancer Biology, Večna pot 121, Ljubljana 1000, Slovenia. Electronic address:
Article Synopsis
- The rising use of new chemicals and consumer products has spurred concerns about their potential to cause DNA damage and significant health issues, leading to a demand for genotoxicity testing data.
- Traditional testing methods involve using laboratory animals, which are expensive and raise ethical issues, prompting the development of more accurate in vitro approaches that minimize animal use.
- In particular, 3D cell models have emerged as promising alternatives to 2D cultures, providing better physiological relevance and predictive data for in vivo conditions, and their use in genotoxicity testing has been increasing, as highlighted in a review of 31 recent studies.
In vitro 3D skin culture and its sustainability in toxicology: a narrative review.
Artif Cells Nanomed Biotechnol
December 2024
ASASIpintar Unit, Pusat PERMATA@Pintar Negara, Universiti Kebangsaan Malaysia, Bangi, Malaysia.
In current toxicological research, 2D cell cultures and animal models are well- accepted and commonly employed methods. However, these approaches have many drawbacks and are distant from the actual environment in human. To embrace this, great efforts have been made to provide alternative methods for non-animal skin models in toxicology studies with the need for more mechanistically informative methods.
View Article and Find Full Text PDFReconciling chemical flame retardant exposure and fire risk in domestic furniture.
PLoS One
December 2023
Centre for Fire and Hazards Science, University of Central Lancashire, Preston, United Kingdom.
Introduction: Evidence suggests that standards for resistance of furniture to ignition may lead to an increase in use of chemical flame retardants (CFRs). This is motivating the development of new approaches that maintain high levels of fire safety while facilitating a reduction in use of CFRs. However, reconciling potential fire risk with use of CFRs in relation to specific policy objectives is challenging.
View Article and Find Full Text PDFApplication of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review.
Biosensors (Basel)
July 2023
Unit of Forensic Medicine, Department of Diagnostics and Public Health, University of Verona, P.le Scuro 10, 37134 Verona, Italy.
Article Synopsis
- - Researchers are focusing on creating rapid, sensitive, and cost-effective analytical methods for detecting intoxication that can be used in non-specialized labs and on-site situations.
- - Paper-based microfluidic analytical devices (μPADs) offer a low-cost alternative to traditional tests and can detect a wide range of toxic compounds, drugs, and substances related to drug-facilitated crimes.
- - The report reviews recent advancements in μPADs in forensic and clinical toxicology, exploring future applications including multisensing devices, microfluidic separations, and wearable sensors.
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