Tissues of adult man and fetus were studied by indirect immunoperoxidase technique using affinity-purified antibodies against placenta-specific alpha 2-microglobulin (APM-2). APM-2 proved to be synthesized mucous membrane cells of uterus during secretory phase of the menstrual cycle. APM-2 was also found in atretic follicle of fertile woman ovary as well as in I order oocytes from the fetus ovary (26 weeks). In men APM-2 is synthesized in seminal vesicles. APM-2 was found both in cytotrophoblast and in syncytiotrophoblast as shown by study of chorionic villi.
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