A study was conducted to investigate how operator exposure in interventional radiology is affected by various common fluoroscopic imaging conditions. Stray radiation levels surrounding the imaging chain of a C-arm angiographic system were measured with an anthropomorphic abdomen phantom under different imaging conditions, and isodose curves were constructed. Operator exposure was shown to increase with patient dose-area product as the imaging field of view (FOV) is changed, with the highest scatter levels occurring with an intermediate-sized FOV. Use of copper spectral beam filtration was found to result in decreased operator exposure, whereas use of wedge-shaped equalization filters was found to increase exposure. The effect of increasing patient abdomen thickness was simulated by surrounding the phantom with plastic bolus material. Increasing the thickness by 5 cm resulted in a doubling of exposure at the operator's waist. Exposure to the operator's upper body was significantly reduced when the FOV was positioned on the far side of the patient. Operator exposure can be maintained at an acceptable level by taking these variables into consideration and incorporating the suggested dose reduction techniques into routine practice to the greatest extent possible.
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http://dx.doi.org/10.1148/rg.265055127 | DOI Listing |
Neurosurg Rev
January 2025
Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi, 74800, Pakistan.
Public and private medical institutes must adhere to the same standards of quality set by the Pakistan Medical & Dental Council (PMDC). However, studies have noted varied learning environments. The current study aims to assess opportunities and compare the differences in perceptions between the two sectors.
View Article and Find Full Text PDFCornea
January 2025
Department of Ophthalmology, Rothschild Foundation, Paris, France; and.
Purpose: The purpose of this study was to investigate the effect of hypoxia and hypobaric conditions on refraction and central corneal thickness on healthy corneas during an ascent without oxygen supplementation above 7000 m (23 000 ft).
Methods: Twelve multinational mountaineers were included in a prospective observational cohort study during an expedition to the Korzhenevskoi Peak (7105 m). The two patients excluded from the study had a history with keratoconus or were current wearers of rigid contact lenses.
J Acquir Immune Defic Syndr
December 2024
Department of Community Health and Social Sciences, CUNY Graduate School of Public Health and Health Policy, New York, NY.
Introduction: Efforts to improve pre-exposure prophylaxis (PrEP) uptake among gay men, transgender women, and Black cisgender women are evident across the United States, responding to epidemiologic data showing a disproportionate HIV burden in these communities. However, transgender men and other transmasculine people who have sex with men (TMSM)-those assigned female at birth who identify otherwise and have sex with cisgender men-are often excluded from these statistics. This community has unique vulnerabilities and prevention needs.
View Article and Find Full Text PDFClin Pharmacol Ther
January 2025
Certara Predictive Technologies Division, Certara UK Limited, Sheffield, UK.
Understanding cytokine-related therapeutic protein-drug interactions (TP-DI) is crucial for effective medication management in conditions characterized by elevated inflammatory responses. Recent FDA and ICH guidelines highlight a systematic, risk-based approach for evaluating these interactions, emphasizing the need for a thorough mechanistic understanding of TP-DIs. This study integrates the physiologically based pharmacokinetic (PBPK) model for TP (specifically interleukin-6, IL-6) with small-molecule drug PBPK models to elucidate cytokine-related TP-DI mechanistically.
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