AI Article Synopsis
- - A new group of pyridine-3-propanoic acids was created and studied for their biological activity.
- - The research revealed some compounds that effectively activate both PPARalpha and PPARgamma receptors, showing different levels of specificity.
- - Two compounds, (S)-14 and (S)-19, were chosen for additional testing based on their effectiveness in diabetic mice and favorable drug absorption and activity characteristics.
Article Abstract
A series of novel pyridine-3-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARalpha/gamma agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, compounds (S)-14 and (S)-19 were selected for further profiling.
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| http://dx.doi.org/10.1016/j.bmcl.2006.08.110 | DOI Listing |
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