AI Article Synopsis
- The prion protein gene of the African lion was cloned, revealing a high degree of genetic uniformity among eight lions, with identical amino acid sequences across all samples.
- Four single nucleotide polymorphisms were identified in the gene, but they did not result in any changes to the amino acid sequence.
- Comparative analysis showed that the African lion's prion protein gene is highly similar to those of domestic cats and sheep, but it has three different amino acid substitutions that could impact the risk of cross-species prion disease transmission.
Article Abstract
The prion protein gene of African lion (Panthera Leo) was first cloned and polymorphisms screened. The results suggest that the prion protein gene of eight African lions is highly homogenous. The amino acid sequences of the prion protein (PrP) of all samples tested were identical. Four single nucleotide polymorphisms (C42T, C81A, C420T, T600C) in the prion protein gene (Prnp) of African lion were found, but no amino acid substitutions. Sequence analysis showed that the higher homology is observed to felis catus AF003087 (96.7%) and to sheep number M31313.1 (96.2%) Genbank accessed. With respect to all the mammalian prion protein sequences compared, the African lion prion protein sequence has three amino acid substitutions. The homology might in turn affect the potential intermolecular interactions critical for cross species transmission of prion disease.
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| http://dx.doi.org/10.1007/s11262-005-0058-0 | DOI Listing |
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