The traditional treatment of Pancoast tumour with local approaches (surgery, radiotherapy or a combination of both) leads to a poor outcome due to the high rate of incomplete resection and the lack of systemic control. The aim of the present prospective feasibility study was to determine whether a trimodality approach improves local control and survival. Patients with stage IIB-IIIB Pancoast tumour received induction chemotherapy (three courses of split-dose cisplatin and etoposide or paclitaxel) followed by concurrent chemoradiotherapy (a course of cisplatin/etoposide combined with 45 Gy hyperfractionated accelerated radiotherapy). After restaging, eligible patients underwent surgery 4-6 weeks post-radiation. A total of 31 consecutive patients with T3 (81%) or T4 (19%) Pancoast tumour were enrolled in the study. Induction chemoradiotherapy was completed in all patients without treatment-related deaths. Grade 3-4 toxicity was observed in 32% of cases. In total, 29 (94%) patients were eligible for surgery. Complete resection was achieved in 94% of patients. The post-operative mortality rate was 6.4% and major complications arose in 20.6% of the patients. The median survival was 54 months with 2- and 5-yr survival rates of 74 and 46%, respectively. In conclusion, this intensive multimodality treatment of Pancoast tumour is feasible and improves local resectability rates and long-term survival as compared with historical series.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1183/09031936.00108205 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pancoast Tumors: 11-Year Single-Centre Experience.
Port J Card Thorac Vasc Surg
October 2024
Thoracic Surgery Department - Hospital de Santa Marta, Centro Hospitalar Universitário Lisboa Central, Portugal.
Introduction: Pancoast tumors encompass any tumor located on the lung apex, extending into structures in the thoracic inlet and, often, leading to the characteristic clinical syndrome. The main goal of this study is to analyze the response to multimodal treatment and outcome of patients with Pancoast tumors.
Materials And Methods: We performed a retrospective cohort single center study of patients with superior sulcus nonsmall cell lung carcinomas who underwent surgery between January of 2011 and February of 2022.
Chest wall resection with robotic-assisted thoracoscopic surgery for a Pancoast tumour: a case report.
Multimed Man Cardiothorac Surg
March 2024
Department of Thoracic Surgery, Norfolk and Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich, NR4 7UY, UK.
Article Synopsis
- The text describes a complex robotic-assisted surgery to remove a right posterior Pancoast tumor using the DaVinci X system, involving multiple surgical ports.
- The procedure involved lobectomy, rib resection, and extensive dissection around the thoracic area, ultimately requiring a small thoracotomy to complete tumor removal due to its invasion into surrounding structures.
- Post-surgery, the patient had a smooth recovery and was discharged after 5 days, with the tumor confirmed as squamous non-small-cell lung cancer; however, a year later, an asymptomatic recurrence was addressed with radiotherapy.
Complex Regional Pain Syndrome-like Pattern in a Case of Pancoast Tumor.
Indian J Nucl Med
December 2023
Department of Nuclear Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Article Synopsis
- A 52-year-old man was diagnosed with a Pancoast tumor and experienced burning pain in his shoulder and chest, along with weakness in shoulder movement and hand grip issues.
- He underwent a Tc bone scan to check for metastasis, which revealed increased activity in the joints and long bones of the affected arm.
- This case emphasizes the need to consider nontraumatic causes for symptoms that resemble complex regional pain syndrome.
Retraction: Schwannoma: A Rare Etiology of Pancoast Syndrome.
Cureus
January 2024
Internal Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.
Article Synopsis
- The article with DOI 10.7759/cureus.19418 has been officially retracted.
- This means that the content of the article is no longer considered valid or reliable.
- The retraction may be due to issues with the research, findings, or errors in the publication process.
A Patient With Pancoast Tumor Presenting With Cervical Radiculopathy: A Case Report.
J Chiropr Med
December 2023
Chiropractic Department, D'Youville College, Buffalo, New York.
Article Synopsis
- The report focuses on a 52-year-old male patient who experienced cervical and arm pain, later diagnosed with a Pancoast tumor after seeking chiropractic care.
- The patient's history revealed a potential link to his symptoms through his prior occupational lifting and an eventual acknowledgment of a long-term smoking habit.
- The case emphasizes the necessity for healthcare providers to consider less common conditions, like apical lung tumors, when evaluating patients with neck and arm pain, highlighting the importance of follow-up on diagnostic imaging results.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!