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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2598590 | PMC |
| http://dx.doi.org/10.1136/sti.2006.022699 | DOI Listing |
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How prevalent are lactoferrin receptors in Gram-negative bacteria?
Biochem Cell Biol
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Department of Microbiology, Immunology, and Infectious Diseases, Snyder Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Surface receptors in Gram-negative bacteria that bind and extract iron from the host glycoproteins transferrin (Tf) or lactoferrin (Lf) was discovered 35 years ago in pathogenic species and subsequently was discovered in other pathogens of humans and food production animals. These bacterial species reside exclusively on the mucosal surfaces of the respiratory or genitourinary tract of their mammalian host and rely on their host specific Tf and Lf receptors to acquire iron for survival. Since the specificity of the bacterial Tf receptors was shown to be due to selective pressures on the host Tf, their presence in bacteria that reside in both mammals and birds indicates that they arose over 320 million years ago.
View Article and Find Full Text PDFAseptic meningitis from herpes simplex virus proctitis.
BMJ Case Rep
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Graduate Medical Education, University of Miami Miller School of Medicine, Fort lauderdale, Florida, USA.
Sexually transmitted proctitis, a prevalent concern among men who have sex with men (MSM) is frequently caused by a range of pathogens, including herpes simplex virus (HSV), and While HSV-associated proctitis typically presents with visible lesions, cases without external manifestations remain evasive. We report the case of an MSM in his early 30s presenting with dyschezia and perineal discomfort after unprotected anoreceptive intercourse. Despite initial inconspicuous findings, rectal swabs revealed HSV-2 infection.
View Article and Find Full Text PDFCommunity pharmacies: Key players in point-of-care diagnostics for STI screening in Africa.
PLoS One
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Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Background: Sexually Transmitted Infections (STIs) rank in the top 5 disease categories for which adults in developing countries seek healthcare services. Community pharmacies offer clients convenience, proximity, extended opening hours, privacy, and efficiency, which could make them desirable locations for HIV and STI screening and treatment. We examined the feasibility of using point-of-care (POC) STI tests for screening HIV and other STIs at community pharmacies.
View Article and Find Full Text PDFA systematic review to identify research gaps in studies modeling MenB vaccinations against Neisseria infections.
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The genus Neisseria includes two major human pathogens: N. meningitidis causing bacterial meningitis/septicemia and N. gonorrhoeae causing gonorrhoea.
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Curr Opin Infect Dis
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Infectious Diseases Unit, Vita-Salute San Raffaele University.
Purpose Of Review: Several microorganisms, which are not traditionally considered sexually transmitted infections (STIs), are capable of sexual transmission and have the potential to cause global outbreaks. The aim of this review is to describe pathogens which are not traditionally defined as STIs, to grant insight on current and potential outbreaks and call for clinical vigilance among members of key populations.
Recent Findings: Recent findings emphasize that several pathogens, not traditionally classified as STIs, can be sexually transmissible.
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