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Patient Perspective on Robotic-Assisted Total Joint Arthroplasty.
Arthroplast Today
February 2025
Georgetown University School of Medicine, MedStar Georgetown University Hospital, Washington, D.C, USA.
Background: Robotic-assisted total joint arthroplasty (TJA) has gained popularity in recent years. Despite mixed patient and surgeon perceptions, conflicting evidence regarding efficacy and cost-effectiveness in comparison to manual TJA exists. Patients' beliefs surrounding robotic-assisted TJA remain unclear.
View Article and Find Full Text PDFBiologics and small molecules: the re-evolution in the treatment of atopic dermatitis in children and adolescents. Current state of the art and future perspectives.
Expert Rev Clin Immunol
January 2025
Department of Woman, Child and of General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', Napoli, Italy.
Introduction: In recent years, the understanding of atopic dermatitis (AD) pathogenetic mechanisms has expanded and now it is recognized that Th2 immune axis dysregulation is pivotal to AD pathogenesis. The advent of biological drugs and small molecules have marked a revolution in the treatment of AD. Dupilumab, targeting IL-4 and IL-13, has been the first to demonstrate efficacy in treating moderate to severe AD by modulating type-2 inflammation pathways.
View Article and Find Full Text PDFA review of imaging in the diagnosis and management of complicated paediatric pneumonia.
Paediatr Respir Rev
December 2024
Faculty of Medicine, University of Wollongong, Wollongong, NSW, Australia; Department of Respiratory Medicine, The Children's Hospital at Westmead, Westmead, NSW, Australia. Electronic address:
Paediatric pneumonia and its complications present substantial health and economic challenges. While chest radiographs are commonly used as the initial imaging modality for diagnosing uncomplicated pneumonia, they are less effective for complicated cases. In response, various imaging techniques, such as lung ultrasound, computed tomography (CT), and chest MRI, have been integrated into clinical practice to enhance diagnosis and guide management decisions.
View Article and Find Full Text PDFEducational Strategies for Teaching Metabolic Profiles Across Three Endurance Training Zones.
Adv Physiol Educ
January 2025
Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, Brazil.
This article explores an innovative educational approach using a metabolic board designed to enhance understanding of muscle metabolism across three endurance training zones: Z1 (light intensity), Z2 (moderate intensity), and Z3 (intense/severe intensity). The aerobic threshold marks the transition from light to moderate domains, and the anaerobic threshold separates moderate from intense domains, with both thresholds adapting to training. Exercises within each training zone elicit specific adaptive responses through distinct signaling pathways, but the metabolic profile induced remains relatively constant across these intensity domains.
View Article and Find Full Text PDFArtificial intelligence in gastrointestinal cancers: diagnostic, prognostic, and surgical strategies.
Cancer Lett
January 2025
School of Medicine, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
GI (Gastrointestinal) malignancies are one of the most common and lethal cancers globally. The dawn of precision medicine and developing technologies have reduced the mortality rates for GI malignancies, underscoring the main role of early detection methods for survival rate improvement. Artificial intelligence (AI) is a new technology that may improve GI cancer screening, treatment, and therapeutic efficiency for better patient care.
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