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Zebrafish and cellular models of SELENON-Congenital myopathy exhibit novel embryonic and metabolic phenotypes.
Skelet Muscle
March 2025
Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Background: SELENON-Congenital Myopathy (SELENON-CM) is a rare congenital myopathy caused by mutations of the SELENON gene characterized by axial muscle weakness and progressive respiratory insufficiency. Muscle histopathology may be non-specific, but commonly includes multiminicores or a dystrophic pattern. The SELENON gene encodes selenoprotein N (SelN), a selenocysteine-containing redox enzyme located in the endo/sarcoplasmic reticulum membrane where it colocalizes with mitochondria-associated membranes.
View Article and Find Full Text PDFEnhancing the accuracy of cup placement in total hip arthroplasty using CT-based navigation by a trainee surgeon: a retrospective cohort study.
BMC Musculoskelet Disord
March 2025
Department of Orthopedic Surgery, Saitama Medical Center, Dokkyo Medical University, 1-1-50 Minami-Koshigaya, Koshigaya City, 343-8555, Saitama, Japan.
Background: The learning curve of total hip arthroplasty (THA) using the anterior approach in the supine position is considered to be long owing to limited surgical field visualization. This study aimed to investigate the learning curve of a trainee's cup placement using computed tomography (CT)-based navigation, focusing on identifying the number of cases required to achieve proficiency.
Methods: This retrospective cohort study included 112 hips that underwent total hip arthroplasty using CT-based navigation via anterolateral approach in the supine position by a trainee surgeon who had performed fewer than 20 prior THA cases.
Time efficiency and precision of splinted complete arch implant scanning.
J Prosthet Dent
March 2025
Associate Professor, Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia. Electronic address:
Statement Of Problem: The precision and accuracy of intraoral scanners for complete arch implant scanning is questionable as it is affected by the absence of anatomic features, the presence of large homogenous areas, and the lack of clear reference points, all of which create inherent errors in the image stitching process by the scanner software program.
Purpose: The purpose of this in vitro study was to test a newly designed scan-aid apparatus for evaluating the effect of geometric heterogeneity and additional reference points on the time efficiency and scanning precision of complete arch implant scanning.
Material And Methods: A total of 60 scans (20 per group) were performed using an intraoral scanner in 3 different clinical simulations: 2 parallel implants, 4 parallel implants, and 4 implants; 2 anterior implants in parallel axial orientation; and 2 distal implants with a 30-degree posterior inclination.
Evaluation of cup placement accuracy in computer assisted total hip arthroplasty.
Arch Orthop Trauma Surg
March 2025
Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Background: Total hip arthroplasty (THA) accuracy has improved significantly with various advances in computer-assisted equipment (CAE), including robotic systems, computed tomography (CT) navigation, and portable navigation. However, no studies have directly compared the accuracy of acetabular cup placement and its impact on patient-reported outcome measures (PROMs) across these three CAE systems. In this study, we aimed to evaluate cup placement accuracy and PROMs in THA using different CAE systems.
View Article and Find Full Text PDFA novel method for harmonization of PET image spatial resolution without phantoms.
EJNMMI Phys
March 2025
Biospective Inc, 1255 Peel Street, Suite 560, Montreal, QC, H3B 2T9, Canada.
Background: Estimation of the spatial resolution in real images is extremely important in several fields, including crystallography, optics, microscopy, and tomography. In human PET imaging, estimating spatial resolution typically involves the acquisition of images from a physical phantom, typically a Hoffman phantom, which poses a logistical burden, especially in large multi-center studies. Indeed, phantom images may not always be readily available, and this method requires constant monitoring of scanner updates or replacements, scanning protocol changes, and image reconstruction guidelines to establish a equivalence with scans acquired from human subjects.
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